摘要：

In recent years, vanadium compounds have attracted the interest of many researchers due to their potential use in diabetes treatment. In order to improve their therapeutic effect, quite a lot of vanadium compounds were synthesized and screened. The structure-activity relationship has been explored. However, the actual therapeutic effect is not only dependent on the pharmacological action, but also on whether an effective level could be established in the target site. In the present work, the bioavailability and the toxicity of the different oxovanadium confounds were studied using human erythrocytes as a model system.

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