高等学校化学学报

高等学校化学学报 ›› 2000, Vol. 21 ›› Issue (S1): 148.

• Chemistry in Life Sciences • 上一篇    下一篇

Cathepsin K Inhibitors for Treatment of Osteoporosis

TIAN Zong-Qiang, PALMER James T., BUYSSE Ann, VENKATRAMAN Shankar, MENDONCA Rohan, MCGRATH Mary E.   

  1. Axys Pharmaceuticals, 180 Kimball Way, South San Francisco, CA 94080, U. S. A
  • 出版日期:2000-12-31 发布日期:2000-12-31

Cathepsin K Inhibitors for Treatment of Osteoporosis

TIAN Zong-Qiang, PALMER James T., BUYSSE Ann, VENKATRAMAN Shankar, MENDONCA Rohan, MCGRATH Mary E.   

  1. Axys Pharmaceuticals, 180 Kimball Way, South San Francisco, CA 94080, U. S. A
  • Online:2000-12-31 Published:2000-12-31

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摘要：

Cysteine Proteases have been implicated in a broad spectrum of disease processes including cancer, arthritis, and viral and parasitie diseases[1]. Cathepsin K, a cysteine protease of the papain superfamily, is selectively expressed in osteoclasts and has been implicated in the process of bone resouption[2]. It is therefore considered a promising therapeutic target for treating diseases charccterized by excessive bone loss, such as osteoporosis[3]. Several chemotypes of cathepsin K inhibitors will be reviewed. The design and synthesis of potent inhibitors will also be discussed.

Abstract:

Cysteine Proteases have been implicated in a broad spectrum of disease processes including cancer, arthritis, and viral and parasitie diseases[1]. Cathepsin K, a cysteine protease of the papain superfamily, is selectively expressed in osteoclasts and has been implicated in the process of bone resouption[2]. It is therefore considered a promising therapeutic target for treating diseases charccterized by excessive bone loss, such as osteoporosis[3]. Several chemotypes of cathepsin K inhibitors will be reviewed. The design and synthesis of potent inhibitors will also be discussed.

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