高等学校化学学报

高等学校化学学报 ›› 2000, Vol. 21 ›› Issue (S1): 147.

• Chemistry in Life Sciences • 上一篇    下一篇

Hypoxia-actived Prodrugs of Diffusible Cytotoxins (HPDCs)——Synthesis and Characterization of Co(Ⅲ) Mustard Complexes and Cytotoxicity in Vitro

YANJun1, HUANG Hong-Jun1, YANG Pin2, CUI Hai-Ping1,2   

  1. 1. Physics-chemistry section, Mechanical Engineering College, Shijiazhuang 050003;
    2. Institute of Molecule Science, Taiyuan 030006
  • 出版日期:2000-12-31 发布日期:2000-12-31

Hypoxia-actived Prodrugs of Diffusible Cytotoxins (HPDCs)——Synthesis and Characterization of Co(Ⅲ) Mustard Complexes and Cytotoxicity in Vitro

YANJun1, HUANG Hong-Jun1, YANG Pin2, CUI Hai-Ping1,2   

  1. 1. Physics-chemistry section, Mechanical Engineering College, Shijiazhuang 050003;
    2. Institute of Molecule Science, Taiyuan 030006
  • Online:2000-12-31 Published:2000-12-31

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摘要：

Hypoxic cells are present in most solid tumors of the men and animals, which occur in the interface between the well-oxygenated tissue and the necrotic regions. Hypoxia can be a direct cause of therapeutic resistance because some drugs and radiation require oxygen to be maximally cytotoxic. Cellular metabolism is altered under hypoxic conditions. In addition there is evidence that Hypoxia can enhance genetic instability in tumor cells thus allowing more rapid development of drug resistance cells.

Abstract:

Hypoxic cells are present in most solid tumors of the men and animals, which occur in the interface between the well-oxygenated tissue and the necrotic regions. Hypoxia can be a direct cause of therapeutic resistance because some drugs and radiation require oxygen to be maximally cytotoxic. Cellular metabolism is altered under hypoxic conditions. In addition there is evidence that Hypoxia can enhance genetic instability in tumor cells thus allowing more rapid development of drug resistance cells.

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