高等学校化学学报

高等学校化学学报 ›› 2000, Vol. 21 ›› Issue (S1): 146.

• Chemistry in Life Sciences • 上一篇    下一篇

Comparison of the Metabolism of Eprinomectin in Lactating Dairy Cattle, Beef Cattle and Rats

ZENG Zhao-Pie, ANDREW Nick, NARASIMHAN Nachu,VENKATARAMAN Kalpana, HALLEY Bruce   

  1. Department of Pharmacokinetics and Drug Metabolism, Merial, 2100 Ronson Road, Iselin, NJ 08830
  • 出版日期:2000-12-31 发布日期:2000-12-31

Comparison of the Metabolism of Eprinomectin in Lactating Dairy Cattle, Beef Cattle and Rats

ZENG Zhao-Pie, ANDREW Nick, NARASIMHAN Nachu,VENKATARAMAN Kalpana, HALLEY Bruce   

  1. Department of Pharmacokinetics and Drug Metabolism, Merial, 2100 Ronson Road, Iselin, NJ 08830
  • Online:2000-12-31 Published:2000-12-31

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摘要：

Eprinomectin is a parasiticide used in beef and dairy cattle. It was not extensively metabolized in either cattle or Spranue-Dawley VAF rats, All the metabolites detected in cattle tissues and milk were also detected in rat tissues and feces. Metabolism of eprinomectin in cattle and rats were qualitalively similar. Therefore the Sprangue-Dawley VAF rat is a good laboratory animal model to evaluate the human food toxicology safety of eprinomectin.

Abstract:

Eprinomectin is a parasiticide used in beef and dairy cattle. It was not extensively metabolized in either cattle or Spranue-Dawley VAF rats, All the metabolites detected in cattle tissues and milk were also detected in rat tissues and feces. Metabolism of eprinomectin in cattle and rats were qualitalively similar. Therefore the Sprangue-Dawley VAF rat is a good laboratory animal model to evaluate the human food toxicology safety of eprinomectin.

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