高等学校化学学报

高等学校化学学报 ›› 2000, Vol. 21 ›› Issue (S1): 145.

• Chemistry in Life Sciences • 上一篇    下一篇

Microfabricated Disposable Electrochemical DNA Sensors

XU Dan-Ke, LIU Zhi-Hong, MA Li-Ren   

  1. Beijing Institute of Radiation Medicine, Chinese National Biomedical Analytical Center, Beijing 10084
  • 出版日期:2000-12-31 发布日期:2000-12-31

Microfabricated Disposable Electrochemical DNA Sensors

XU Dan-Ke, LIU Zhi-Hong, MA Li-Ren   

  1. Beijing Institute of Radiation Medicine, Chinese National Biomedical Analytical Center, Beijing 10084
  • Online:2000-12-31 Published:2000-12-31

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摘要：

Hybridization analysis is one of the most powerful methods of nucleic acid assays, including diagnostics of genetic disorders and infections of various etiologies. The biosensor detection allows an assay to be simplified and automatized[1,2]. In this report a new electrochemical biosensing method based on coupling avidin-alkaline phosphatase(AV-AP) to the biotinylated oligonucleotide has been developed.

Abstract:

Hybridization analysis is one of the most powerful methods of nucleic acid assays, including diagnostics of genetic disorders and infections of various etiologies. The biosensor detection allows an assay to be simplified and automatized[1,2]. In this report a new electrochemical biosensing method based on coupling avidin-alkaline phosphatase(AV-AP) to the biotinylated oligonucleotide has been developed.

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