高等学校化学学报

高等学校化学学报 ›› 2000, Vol. 21 ›› Issue (S1): 144.

• Chemistry in Life Sciences • 上一篇    下一篇

Design, Synthesis of N-benzoyloxy-thiono-1,8-naphthalimides as Novel DNA Photocleavers

QIAN Xu-Hong1, YAO Wei2, CHEN Gang2   

  1. 1. State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian 116012;
    2. Institute of Pesticides & Pharmaceuticals, East China University of Science and Technology, Shanghai 200237
  • 出版日期:2000-12-31 发布日期:2000-12-31

Design, Synthesis of N-benzoyloxy-thiono-1,8-naphthalimides as Novel DNA Photocleavers

QIAN Xu-Hong1, YAO Wei2, CHEN Gang2   

  1. 1. State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian 116012;
    2. Institute of Pesticides & Pharmaceuticals, East China University of Science and Technology, Shanghai 200237
  • Online:2000-12-31 Published:2000-12-31

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摘要：

In recent years, It is of great interest to the design and synthesis of DNA photocleaving reagents that can generate active species by long-wavelength UV-light (λ>350nm) or more preferably by visible light irradiation. Our studies are based upon 1,8-naphthalimide-derivitives, which usually exhibit strong visible absorption and good DNA intercalative binding abilities.

Abstract:

In recent years, It is of great interest to the design and synthesis of DNA photocleaving reagents that can generate active species by long-wavelength UV-light (λ>350nm) or more preferably by visible light irradiation. Our studies are based upon 1,8-naphthalimide-derivitives, which usually exhibit strong visible absorption and good DNA intercalative binding abilities.

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