高等学校化学学报

高等学校化学学报 ›› 2000, Vol. 21 ›› Issue (S1): 141.

• Chemistry in Life Sciences • 上一篇    下一篇

Ab Initio and MNDO Calculation of the Intermediates of N-Diisopropylphosphoryl L-lspartic Acid

CHEN Zhong-Zhou, TAN Bo, LI Yan-Mei, ZHAO Yu-Fen   

  1. Bioorganic Phosphorus Chemistry Laboratory, Department of Chemistry, Tsinghua University, Beijing 100084
  • 出版日期:2000-12-31 发布日期:2000-12-31

Ab Initio and MNDO Calculation of the Intermediates of N-Diisopropylphosphoryl L-lspartic Acid

CHEN Zhong-Zhou, TAN Bo, LI Yan-Mei, ZHAO Yu-Fen   

  1. Bioorganic Phosphorus Chemistry Laboratory, Department of Chemistry, Tsinghua University, Beijing 100084
  • Online:2000-12-31 Published:2000-12-31

PDF (PC)

摘要：

Many biological processes are regulated by the phosphorylation and dephosphorylation of amino acid residues in the proteins[1]. High-coordinate phosphorus intermediates forming from amino acid residues in protein are of great importance in the process of phosphorylation and dephosphorylation of protein. It has been proposed that the mechanisms of phosphorylation through penta-coordinate intramolecular mixed carboxylic-phosphoric anhydride intermediates[2]. It was found that α-COOH group[3] and β-COOH group[4] in aspartic acid had different activities in the ester exchange on phosphorus. So it is important to discuss which carboxylic acids is involved in the penta-coordinate phosphorus intermediate of aspartic acid.

Abstract:

Many biological processes are regulated by the phosphorylation and dephosphorylation of amino acid residues in the proteins[1]. High-coordinate phosphorus intermediates forming from amino acid residues in protein are of great importance in the process of phosphorylation and dephosphorylation of protein. It has been proposed that the mechanisms of phosphorylation through penta-coordinate intramolecular mixed carboxylic-phosphoric anhydride intermediates[2]. It was found that α-COOH group[3] and β-COOH group[4] in aspartic acid had different activities in the ester exchange on phosphorus. So it is important to discuss which carboxylic acids is involved in the penta-coordinate phosphorus intermediate of aspartic acid.

TrendMD: