高等学校化学学报

高等学校化学学报 ›› 2000, Vol. 21 ›› Issue (S1): 137.

• Chemistry in Life Sciences • 上一篇    下一篇

Interaction of Phenylpropanoid Glycosides with Nucleotides and DNA:Kinetic and Molecular Modeling Study

FAN B. T.1, ZHENG R.2, ZAKRZEWSKA K.3, JIA Z.4, SHI Y.2, PANAYE A.2, DOUCET J. P.1, FASSIN. El1, DELALANDE O.1   

  1. 1. ITODYS, CNRS UPRES-A 7086, Universit éParis7, 1, rue Guy de la Brosse, 75005 Paris, France;
    2. State Key Laboratory of Applied Organic Chemistry, Lanzhou Universiy, 73000, China;
    3. Laboratoire de Biochimie Th éorique, IBPC, 75005 Paris, France;
    4. Department of Biology, Lanzhou Universiy, 73000, Chian
  • 出版日期:2000-12-31 发布日期:2000-12-31

Interaction of Phenylpropanoid Glycosides with Nucleotides and DNA:Kinetic and Molecular Modeling Study

FAN B. T.1, ZHENG R.2, ZAKRZEWSKA K.3, JIA Z.4, SHI Y.2, PANAYE A.2, DOUCET J. P.1, FASSIN. El1, DELALANDE O.1   

  1. 1. ITODYS, CNRS UPRES-A 7086, Universit éParis7, 1, rue Guy de la Brosse, 75005 Paris, France;
    2. State Key Laboratory of Applied Organic Chemistry, Lanzhou Universiy, 73000, China;
    3. Laboratoire de Biochimie Th éorique, IBPC, 75005 Paris, France;
    4. Department of Biology, Lanzhou Universiy, 73000, Chian
  • Online:2000-12-31 Published:2000-12-31

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摘要：

Phenylpropanoid glycosides (PPGs) are substances extracted from Pedicularis. They have been largely studied for their interesting biological and pharmacological properties[1-3], in particular, their double role in the protection of DNA:preventing the DNA bases from radical attack, and rapidly repairing damaged DNA[4-6]. A series of kinetic measurements has been performed with different deoxynucleotide radicals. Two major remakes can be done from the experimental results:(1) the reactivity of PPGs seems to depend on the number of phenolic hydroxyl groups; (2) the reactivity depends upon the positions of these groups. These observations are in agreements with the experiments performed on tumour cells.

Abstract:

Phenylpropanoid glycosides (PPGs) are substances extracted from Pedicularis. They have been largely studied for their interesting biological and pharmacological properties[1-3], in particular, their double role in the protection of DNA:preventing the DNA bases from radical attack, and rapidly repairing damaged DNA[4-6]. A series of kinetic measurements has been performed with different deoxynucleotide radicals. Two major remakes can be done from the experimental results:(1) the reactivity of PPGs seems to depend on the number of phenolic hydroxyl groups; (2) the reactivity depends upon the positions of these groups. These observations are in agreements with the experiments performed on tumour cells.

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