高等学校化学学报

高等学校化学学报 ›› 1998, Vol. 19 ›› Issue (S1): 88.

• Organic Synthesis Chemistry • 上一篇    下一篇

Synthesis And 3D-QSAR of Substituted Hydroxycarboxylates

Wenxiang HU, Momen LU, Yunzhang RAN, Liuhong YUN, Jianying WAN, G Jiaju ZHOU, Qian XIE   

  1. The Centre of Research and Development of Medicine and Pharmaceuticals, Commission of Science & Technology and Industry for National Defence, Beijing 100101
  • 出版日期:1998-12-31 发布日期:1998-12-31

Synthesis And 3D-QSAR of Substituted Hydroxycarboxylates

Wenxiang HU, Momen LU, Yunzhang RAN, Liuhong YUN, Jianying WAN, G Jiaju ZHOU, Qian XIE   

  1. The Centre of Research and Development of Medicine and Pharmaceuticals, Commission of Science & Technology and Industry for National Defence, Beijing 100101
  • Online:1998-12-31 Published:1998-12-31

PDF (PC)

摘要： Soman is a neural organophosphorus agent. The prophylatic and treatment of soman caused neural disease is very difficult. Hence research or discovery of potent antisoman drugs is very important in life science and the protective medicine against chemical weapons. Most of anticholinergic compounds are only muscarinic receptor antagonists with very weak affinity to nicotinic receptor. Therefore they have poor efficiency against soman poisoning.

Abstract: Soman is a neural organophosphorus agent. The prophylatic and treatment of soman caused neural disease is very difficult. Hence research or discovery of potent antisoman drugs is very important in life science and the protective medicine against chemical weapons. Most of anticholinergic compounds are only muscarinic receptor antagonists with very weak affinity to nicotinic receptor. Therefore they have poor efficiency against soman poisoning.

TrendMD: