高等学校化学学报 ›› 1998, Vol. 19 ›› Issue (S1): 84.

• Organic Synthesis Chemistry • 上一篇    下一篇

Synthesis of 1,4-Bis(chloromethyl) Benzene with Different Alkoxy-Substituents

Jianying WANG1, Yinkui LI2, Wenxiang HU1, Yongfu LONG2, Shengjian TAN1   

  1. 1. The Centre of Research and Development of Medicine and Pharmaceuticals, Commission of Science & Technology and Industry for National Defence, Beijing 100101;
    2. Department of Material Engineering and Applied Chemistry, National University of Defence Technology, Changsha 410073
  • 出版日期:1998-12-31 发布日期:1998-12-31

Synthesis of 1,4-Bis(chloromethyl) Benzene with Different Alkoxy-Substituents

Jianying WANG1, Yinkui LI2, Wenxiang HU1, Yongfu LONG2, Shengjian TAN1   

  1. 1. The Centre of Research and Development of Medicine and Pharmaceuticals, Commission of Science & Technology and Industry for National Defence, Beijing 100101;
    2. Department of Material Engineering and Applied Chemistry, National University of Defence Technology, Changsha 410073
  • Online:1998-12-31 Published:1998-12-31

摘要: l,4-Bis(chloromethyl) benzene (BCMB) and its derivatives are very important intermediates of much synthetic reaction. Especially, they can be used to synthesize poly(p-phenylene vinylene) (PPV) and its alkoxy derivatives, which have aroused significant interest in recent years[l,2]. So people pays close attention to the synthesis of BCMB derivatives. There are several methods to synthesize BCMB derivatives, such as applying HCHO or (HCHO)n with concentrated hydrochloric acid or anhydrous HCl in the presence of zinc chloride, adopting (HCHO)n with hydrochloric acid in acetic acid aqueous, or utilizing HCHO reacts with hydrochloric acid and bubbles anhydrous HCl which was so called Wood method[3].The methods mentioned above usually affored low yield of BCMB substituted by long alkoxy group, while the synthesis of BCMB with long alkoxy-substituents are the essential for the synthesis of soluble PPV derivatives[4,5].

Abstract: l,4-Bis(chloromethyl) benzene (BCMB) and its derivatives are very important intermediates of much synthetic reaction. Especially, they can be used to synthesize poly(p-phenylene vinylene) (PPV) and its alkoxy derivatives, which have aroused significant interest in recent years[l,2]. So people pays close attention to the synthesis of BCMB derivatives. There are several methods to synthesize BCMB derivatives, such as applying HCHO or (HCHO)n with concentrated hydrochloric acid or anhydrous HCl in the presence of zinc chloride, adopting (HCHO)n with hydrochloric acid in acetic acid aqueous, or utilizing HCHO reacts with hydrochloric acid and bubbles anhydrous HCl which was so called Wood method[3].The methods mentioned above usually affored low yield of BCMB substituted by long alkoxy group, while the synthesis of BCMB with long alkoxy-substituents are the essential for the synthesis of soluble PPV derivatives[4,5].

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