高等学校化学学报

高等学校化学学报 ›› 1998, Vol. 19 ›› Issue (S1): 448.

• Physical Organic Chemistry • 上一篇    下一篇

Structural Analysis of Simvastatin

Zuo Yumin1, Xu Jie2, Ren Sumei2   

  1. 1. Department of Chemistry, Nankai University, Tianjin 300071;
    2. Institute of Fine Chemical, Qingdao Ocean University, Shandong 266003
  • 出版日期:1998-12-31 发布日期:1998-12-31

Structural Analysis of Simvastatin

Zuo Yumin1, Xu Jie2, Ren Sumei2   

  1. 1. Department of Chemistry, Nankai University, Tianjin 300071;
    2. Institute of Fine Chemical, Qingdao Ocean University, Shandong 266003
  • Online:1998-12-31 Published:1998-12-31

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摘要： Compactin(1) and lovastatin(2) are potent inhibitors of cholesterol biosynthesis in humans, and the more active semisynthetic derivative simvastatin(3) are pharmacologically useful compounds for lowering of serum cholesterol levels, The structure of simvastatin and related compounds is shown in Fig.1. It contains a hexahydronaphthalene ring system, a β-hydroxylactone and dimethylbutyrate structural unit.

Abstract: Compactin(1) and lovastatin(2) are potent inhibitors of cholesterol biosynthesis in humans, and the more active semisynthetic derivative simvastatin(3) are pharmacologically useful compounds for lowering of serum cholesterol levels, The structure of simvastatin and related compounds is shown in Fig.1. It contains a hexahydronaphthalene ring system, a β-hydroxylactone and dimethylbutyrate structural unit.

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