高等学校化学学报

高等学校化学学报 ›› 1998, Vol. 19 ›› Issue (S1): 430.

• Physical Organic Chemistry • 上一篇    下一篇

Cyclopeptides incorporating pyridine subunit as new receptors for phosphomonoester

Linjing Mu, Jinpei Cheng, Hai Huang, Xiaohu Gao, Jianming Lu   

  1. Department of Chemistry, Nankai University, Tianjin 300071
  • 出版日期:1998-12-31 发布日期:1998-12-31
  • 通讯作者: Jinpei Cheng
  • 基金资助:
    Postdoctoral Science Foundation of China

Cyclopeptides incorporating pyridine subunit as new receptors for phosphomonoester

Linjing Mu, Jinpei Cheng, Hai Huang, Xiaohu Gao, Jianming Lu   

  1. Department of Chemistry, Nankai University, Tianjin 300071
  • Online:1998-12-31 Published:1998-12-31
  • Contact: Jinpei Cheng
  • Supported by:
    Postdoctoral Science Foundation of China

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摘要： Phosphates play a crucial role in a wide range of biological processes. Numerous efforts have been devoted to molecular recognition, transport and catalytic hydrolysis of phosphate1-4. Recent reports have shown that molecules containing several hydrogen-bonding group directed into a cleft or cavity can effectively recognize phosphate5,6. We now report a new family of pseudo-cyclopeptides 1-4 as receptors for phosphomonoester, which were synthesized by the reaction of pyridine 2,6-dicarbonyl dichloride with cystine bis-peptides(H2N-Xaa-Cyst-Xaa-NH2) dimethylester leading to a variety of 1+1 cystine-based cyclic peptides with the general structure cyclo(Py-CONH-Xaa-Cyst-Xaa-NHCO-) (Cyst=L-cystine dimethyl ester; Xaa=amino acid X) and identified by conventional spectroscopic methods7.

Abstract: Phosphates play a crucial role in a wide range of biological processes. Numerous efforts have been devoted to molecular recognition, transport and catalytic hydrolysis of phosphate1-4. Recent reports have shown that molecules containing several hydrogen-bonding group directed into a cleft or cavity can effectively recognize phosphate5,6. We now report a new family of pseudo-cyclopeptides 1-4 as receptors for phosphomonoester, which were synthesized by the reaction of pyridine 2,6-dicarbonyl dichloride with cystine bis-peptides(H2N-Xaa-Cyst-Xaa-NH2) dimethylester leading to a variety of 1+1 cystine-based cyclic peptides with the general structure cyclo(Py-CONH-Xaa-Cyst-Xaa-NHCO-) (Cyst=L-cystine dimethyl ester; Xaa=amino acid X) and identified by conventional spectroscopic methods7.

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