高等学校化学学报

高等学校化学学报 ›› 1998, Vol. 19 ›› Issue (S1): 428.

• Physical Organic Chemistry • 上一篇    下一篇

Determination of N-NO Bond Heterolysis and Homolysis Energies of Nitrosoureas and Nitrosothioureas

Jin-Pei Cheng, Ming Xian, Xiaoqing Zhu, Yongkai Sun, Linjing Mu   

  1. Department of Chemistry, Nankai University, Tianjin 300071
  • 出版日期:1998-12-31 发布日期:1998-12-31
  • 通讯作者: Jin-Pei Cheng
  • 基金资助:
    This work was supported by grants from NSFC and ministry of Education of China

Determination of N-NO Bond Heterolysis and Homolysis Energies of Nitrosoureas and Nitrosothioureas

Jin-Pei Cheng, Ming Xian, Xiaoqing Zhu, Yongkai Sun, Linjing Mu   

  1. Department of Chemistry, Nankai University, Tianjin 300071
  • Online:1998-12-31 Published:1998-12-31
  • Contact: Jin-Pei Cheng
  • Supported by:
    This work was supported by grants from NSFC and ministry of Education of China

PDF (PC)

摘要： There is currently great interest in the chemistry of nitric oxide (NO) following many important discoveries showing that NO is involved in a range of human physiological processes.1 Among ocean of researches in this area, some attention has been paid on the release of NO from aromatic N-nitrosoureas,not only from the point of view of their potential therapeutical use as alternative NO-releasing drugs,2 but also with regard to their possible involvement in vivo as potential NO-storage and transport vehicles.3 Thus, the cytoxicity mediated by NO is expected to be potent in aromatic N-nitrosoureas having NO-releasing ability. For NO-donor compounds, homolytic cleavage energy of N-NO bond (ΔHhomo) is considered a good measure of their NO-releasing ability. Here, we provide a method to derive the ΔHhomo data and present some results showing structure influence on the N-NO bond strengthes for several series of disubstituted ureas and thioureas.

Abstract: There is currently great interest in the chemistry of nitric oxide (NO) following many important discoveries showing that NO is involved in a range of human physiological processes.1 Among ocean of researches in this area, some attention has been paid on the release of NO from aromatic N-nitrosoureas,not only from the point of view of their potential therapeutical use as alternative NO-releasing drugs,2 but also with regard to their possible involvement in vivo as potential NO-storage and transport vehicles.3 Thus, the cytoxicity mediated by NO is expected to be potent in aromatic N-nitrosoureas having NO-releasing ability. For NO-donor compounds, homolytic cleavage energy of N-NO bond (ΔHhomo) is considered a good measure of their NO-releasing ability. Here, we provide a method to derive the ΔHhomo data and present some results showing structure influence on the N-NO bond strengthes for several series of disubstituted ureas and thioureas.

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