高等学校化学学报

高等学校化学学报 ›› 1998, Vol. 19 ›› Issue (S1): 401.

• Physical Organic Chemistry • 上一篇    下一篇

3D-SAR And A novel Molecular Pharmacology Model of Cholinergic And Anticholinergic Drugs

Wenxiang HU, Liuhcmg YUN, Jianying WANG, Jianshe WANG, Shengjian TAN   

  1. The Centre of Research and Development of Medicine and Pharmaceuticals, Commission of Sciencc & Technology and Industry for National Denfence, Beijing 100101
  • 出版日期:1998-12-31 发布日期:1998-12-31

3D-SAR And A novel Molecular Pharmacology Model of Cholinergic And Anticholinergic Drugs

Wenxiang HU, Liuhcmg YUN, Jianying WANG, Jianshe WANG, Shengjian TAN   

  1. The Centre of Research and Development of Medicine and Pharmaceuticals, Commission of Sciencc & Technology and Industry for National Denfence, Beijing 100101
  • Online:1998-12-31 Published:1998-12-31

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摘要： Anticholinergic drugs have been widely used for many years in neurological research field and clinicial therapy of many dieases, such as parkinsonism stomachache and the organophosphorus agents poisoning. It is important that investigating the conformation-activity relationship (CAR), 3D-QSAR and molecular pharmacology of these compounds to aid in die design highly selective drugs and explain many phenomena understood difficultly,including the similar biological effects for various compounds and different effects for a single compound.

Abstract: Anticholinergic drugs have been widely used for many years in neurological research field and clinicial therapy of many dieases, such as parkinsonism stomachache and the organophosphorus agents poisoning. It is important that investigating the conformation-activity relationship (CAR), 3D-QSAR and molecular pharmacology of these compounds to aid in die design highly selective drugs and explain many phenomena understood difficultly,including the similar biological effects for various compounds and different effects for a single compound.

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