高等学校化学学报 ›› 1998, Vol. 19 ›› Issue (S1): 36.
• Organic Synthesis Chemistry • 上一篇 下一篇
Daqiang Xu, Kapa Prasad, Oljan Repic, Thomas J. Blacklock
Daqiang Xu, Kapa Prasad, Oljan Repic, Thomas J. Blacklock
摘要: 1,3-Diaryl-4-pyrazoleacetic acids and derivatives exhibit multiple biological activities.1 For example, Lonazolac® is listed in Merck index as an antiinflammatory and analgesic agent. We were interested in this type of compounds for their potential applications in anti-diabetics. One of the leading candidates, SDZ RGU 825,has been shown to enhance whole-body glucose disposal without increasing insulin secretion. Therefore, it was developed for treatment of "non-insulin-dependent diabetes mellitus",the type Ⅱ diabetics.
TrendMD: