高等学校化学学报 ›› 1998, Vol. 19 ›› Issue (S1): 36.

• Organic Synthesis Chemistry • 上一篇    下一篇

A General and Facile Synthesis of l,3-Diaryl-4-pyrazoleacetic Acids and Its Application in the Synthesis of SDZ RGU 825

Daqiang Xu, Kapa Prasad, Oljan Repic, Thomas J. Blacklock   

  1. Process R & D, CHAD, Novartis Pharmaceuticals Corporation 59 Route 10, East Hanover, NJ 07936, USA
  • 出版日期:1998-12-31 发布日期:1998-12-31

A General and Facile Synthesis of l,3-Diaryl-4-pyrazoleacetic Acids and Its Application in the Synthesis of SDZ RGU 825

Daqiang Xu, Kapa Prasad, Oljan Repic, Thomas J. Blacklock   

  1. Process R & D, CHAD, Novartis Pharmaceuticals Corporation 59 Route 10, East Hanover, NJ 07936, USA
  • Online:1998-12-31 Published:1998-12-31

摘要: 1,3-Diaryl-4-pyrazoleacetic acids and derivatives exhibit multiple biological activities.1 For example, Lonazolac® is listed in Merck index as an antiinflammatory and analgesic agent. We were interested in this type of compounds for their potential applications in anti-diabetics. One of the leading candidates, SDZ RGU 825,has been shown to enhance whole-body glucose disposal without increasing insulin secretion. Therefore, it was developed for treatment of "non-insulin-dependent diabetes mellitus",the type Ⅱ diabetics.

Abstract: 1,3-Diaryl-4-pyrazoleacetic acids and derivatives exhibit multiple biological activities.1 For example, Lonazolac® is listed in Merck index as an antiinflammatory and analgesic agent. We were interested in this type of compounds for their potential applications in anti-diabetics. One of the leading candidates, SDZ RGU 825,has been shown to enhance whole-body glucose disposal without increasing insulin secretion. Therefore, it was developed for treatment of "non-insulin-dependent diabetes mellitus",the type Ⅱ diabetics.

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