高等学校化学学报

高等学校化学学报 ›› 1998, Vol. 19 ›› Issue (S1): 358.

• Organometallic Chemistry • 上一篇    下一篇

Synthesis of Novel Organogermanium Compounds containing Phosphoryl Groups and Bioactivities of Products

Wang Qingmin, Zeng Xianshun, Cui Tao, Zeng Qiang   

  1. Research Institute of Elemento-Organic Chemistry, State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin 300071
  • 出版日期:1998-12-31 发布日期:1998-12-31
  • 基金资助:
    This project is supported by the National Natural Science Foundation of China and by the State Key Laboratory of Elemento-Organic Chemistry

Synthesis of Novel Organogermanium Compounds containing Phosphoryl Groups and Bioactivities of Products

Wang Qingmin, Zeng Xianshun, Cui Tao, Zeng Qiang   

  1. Research Institute of Elemento-Organic Chemistry, State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin 300071
  • Online:1998-12-31 Published:1998-12-31
  • Supported by:
    This project is supported by the National Natural Science Foundation of China and by the State Key Laboratory of Elemento-Organic Chemistry

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摘要： The β-trialkylgermanyl propanoic acid、β-triphenylgermanyl propanoic acid and their derivatives exhibit anti-inflaxnmatory and antibacteria activities[1]. And both phosphonic acids and their derivatives have bioactivities, e.g. antibacteria[2]、antitumor[3],etc. But synthesis and bioactivities of organogermanium compounds containing phosphoryl structures have seldom been reported. In order to look for new compounds having potent efficient anticancer and antiinflammatory activities, We designed and synthesized organogermanium compounds containing phosphoryl groups Ⅰ and Ⅱ,and studied the methods of synthesis, as well as structures and properties of the products.

Abstract: The β-trialkylgermanyl propanoic acid、β-triphenylgermanyl propanoic acid and their derivatives exhibit anti-inflaxnmatory and antibacteria activities[1]. And both phosphonic acids and their derivatives have bioactivities, e.g. antibacteria[2]、antitumor[3],etc. But synthesis and bioactivities of organogermanium compounds containing phosphoryl structures have seldom been reported. In order to look for new compounds having potent efficient anticancer and antiinflammatory activities, We designed and synthesized organogermanium compounds containing phosphoryl groups Ⅰ and Ⅱ,and studied the methods of synthesis, as well as structures and properties of the products.

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