高等学校化学学报

高等学校化学学报 ›› 1998, Vol. 19 ›› Issue (S1): 356.

• Organometallic Chemistry • 上一篇    下一篇

Synthesis of Novel Organogermanium Sesquioxides and Reactivities of 3-(Trichlorogermyl)propanoic Acid

Wang Qingmin, Zeng Xianshun, Cui Tao, Zeng Qiang   

  1. Research Institute of Elemento-Organic Chemistry, State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin 300071
  • 出版日期:1998-12-31 发布日期:1998-12-31
  • 基金资助:
    This project was supported by the National Natural Science Foundation of China and by the State Key Laboratory of Elemento-Organic Chemistry

Synthesis of Novel Organogermanium Sesquioxides and Reactivities of 3-(Trichlorogermyl)propanoic Acid

Wang Qingmin, Zeng Xianshun, Cui Tao, Zeng Qiang   

  1. Research Institute of Elemento-Organic Chemistry, State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin 300071
  • Online:1998-12-31 Published:1998-12-31
  • Supported by:
    This project was supported by the National Natural Science Foundation of China and by the State Key Laboratory of Elemento-Organic Chemistry

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摘要： During the past two decades, carboxyethylgermanium sesquioxide Ge-132[O3(GeCH2CH2COOH)2] and its derivatives have attracted considerable attention because these organogermanium sesquioxides exhibited anticancer activities[1,2]. In 1993, Kurono et al. have synthesized phosphonoethylgermanium sesquioxide[O3/2GeCH2CH2PO(OH)2], which possesses higher antitumor activity than Ge-132[3]. Encouraged by these promising results, we developed the idea that the incorporation of a germanium residue into α-aminophosphonic acids and their derivatives, which have antibacteria and antitumor activities[4,5], would enhance their antitumor activities to a significant degree, while their toxicity would be reduced at the same time. Therefore, we designed and synthesized a series of novel organogermanium sesquioxides containing α-aminophosphonate groups by the hydrolysis of O,O-diphenyl N-trichlorogermyl propiono-α-aminophosphonates.

Abstract: During the past two decades, carboxyethylgermanium sesquioxide Ge-132[O3(GeCH2CH2COOH)2] and its derivatives have attracted considerable attention because these organogermanium sesquioxides exhibited anticancer activities[1,2]. In 1993, Kurono et al. have synthesized phosphonoethylgermanium sesquioxide[O3/2GeCH2CH2PO(OH)2], which possesses higher antitumor activity than Ge-132[3]. Encouraged by these promising results, we developed the idea that the incorporation of a germanium residue into α-aminophosphonic acids and their derivatives, which have antibacteria and antitumor activities[4,5], would enhance their antitumor activities to a significant degree, while their toxicity would be reduced at the same time. Therefore, we designed and synthesized a series of novel organogermanium sesquioxides containing α-aminophosphonate groups by the hydrolysis of O,O-diphenyl N-trichlorogermyl propiono-α-aminophosphonates.

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