高等学校化学学报

高等学校化学学报 ›› 1998, Vol. 19 ›› Issue (S1): 351.

• Organometallic Chemistry • 上一篇    下一篇

Synthesis of 3-(α-Phenyl-phosphonomethyl)-quinazoline-2,4(1H,3H)-diones

Li Zaiguo, Huang Runqiu, Li Huiying, Liu Xin   

  1. Institute of Elemento-Organic Chemistry, State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin 300071
  • 出版日期:1998-12-31 发布日期:1998-12-31

Synthesis of 3-(α-Phenyl-phosphonomethyl)-quinazoline-2,4(1H,3H)-diones

Li Zaiguo, Huang Runqiu, Li Huiying, Liu Xin   

  1. Institute of Elemento-Organic Chemistry, State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin 300071
  • Online:1998-12-31 Published:1998-12-31

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摘要： α-Aminoalkylphosphonic acids have attracted much attention due to their wide range of biological activities. They serve for inhibiting enzyme activity, bacterial growth and in agrochemistry as antifungal agents, herbicides and plant regulators[1]. In a recent report, α-aminoalkylphosphonates showed very good inhibitory effects against plant virus[2]. At the same time, some derivatives of quinazoline-2,4(1H,3H)-dione also exhibit antiphytoviral activity[3,4]. Considering the wide applications of such compounds, we designed to synthesize some novel quinazoline-2,4(1H,3H)-diones with α-amino-alkylphosphonates moiety, e.g. 3-(α-phenyl-phosphonomethyl)quinazoline-2,4(1H,3H)-dione 4 (scheme Ⅰ).

Abstract: α-Aminoalkylphosphonic acids have attracted much attention due to their wide range of biological activities. They serve for inhibiting enzyme activity, bacterial growth and in agrochemistry as antifungal agents, herbicides and plant regulators[1]. In a recent report, α-aminoalkylphosphonates showed very good inhibitory effects against plant virus[2]. At the same time, some derivatives of quinazoline-2,4(1H,3H)-dione also exhibit antiphytoviral activity[3,4]. Considering the wide applications of such compounds, we designed to synthesize some novel quinazoline-2,4(1H,3H)-diones with α-amino-alkylphosphonates moiety, e.g. 3-(α-phenyl-phosphonomethyl)quinazoline-2,4(1H,3H)-dione 4 (scheme Ⅰ).

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