高等学校化学学报

高等学校化学学报 ›› 1998, Vol. 19 ›› Issue (S1): 349.

• Organometallic Chemistry • 上一篇    下一篇

Synthesis of Phosphorus Derivatives of Pyrazolo[3,4-d]pyrimidine

Li Zaiguo, Huang Runqiu, Li Huiying, Liu Xin   

  1. Institute of Elemento-Organic Chemistry, State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin 300071
  • 出版日期:1998-12-31 发布日期:1998-12-31

Synthesis of Phosphorus Derivatives of Pyrazolo[3,4-d]pyrimidine

Li Zaiguo, Huang Runqiu, Li Huiying, Liu Xin   

  1. Institute of Elemento-Organic Chemistry, State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin 300071
  • Online:1998-12-31 Published:1998-12-31

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摘要： Pyrazolo[3.4-d]pyrimidines are of considerable chemical and pharmacological importance as purine analogs[1]. Various related compounds of these also show anti-tumor, anti-leukemic and antiviral activities[2,3]. In addition,α-aminoalkylphosphonic acid are well known for their wide range of biological activities. They serve in agrochemistry as antifungal agents, herbicides and plant regulators[4]. Recently, it was discovered that some derivatives of α-aminoalkylphosphonic acid also exhibit good antiphytoviral activity[5]. As an extension of our studies on plant virucides, we now wish to report the synthesis of some novel phosphorus derivatives of pyrazolo[3,4-d]pyrimidine-6-ones 4,which may have antiviral activity.

Abstract: Pyrazolo[3.4-d]pyrimidines are of considerable chemical and pharmacological importance as purine analogs[1]. Various related compounds of these also show anti-tumor, anti-leukemic and antiviral activities[2,3]. In addition,α-aminoalkylphosphonic acid are well known for their wide range of biological activities. They serve in agrochemistry as antifungal agents, herbicides and plant regulators[4]. Recently, it was discovered that some derivatives of α-aminoalkylphosphonic acid also exhibit good antiphytoviral activity[5]. As an extension of our studies on plant virucides, we now wish to report the synthesis of some novel phosphorus derivatives of pyrazolo[3,4-d]pyrimidine-6-ones 4,which may have antiviral activity.

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