高等学校化学学报

高等学校化学学报 ›› 1998, Vol. 19 ›› Issue (S1): 347.

• Organometallic Chemistry • 上一篇    下一篇

AN EFFICIENT SYNTHESIS OF ALIPHATIC α-ORGANOTHIO ALDOXIME

Xin Liu, RuiLan Shao, RunQiu Huang   

  1. Research Institute of Elemento-Organic Chemistry, Nankai University Tianjin 300071
  • 出版日期:1998-12-31 发布日期:1998-12-31

AN EFFICIENT SYNTHESIS OF ALIPHATIC α-ORGANOTHIO ALDOXIME

Xin Liu, RuiLan Shao, RunQiu Huang   

  1. Research Institute of Elemento-Organic Chemistry, Nankai University Tianjin 300071
  • Online:1998-12-31 Published:1998-12-31

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摘要： The importance of the aliphatic α-organothio aldoxime compound 3 in the preparation of various pesticides is well established. Molecules comprising the α-organothio oxime moiety have been reported to exhibit insecticidal,nematocidal,miticidal activities.[1-2] In the synthesis of the compound 3,the chlorination of the corresponding aliphatic aldoxime 1 is the key step.In conventional methods, the aliphatic aldoxime 1 is chlorinated by chlorine,then the resulting hydroxime acid chloride 2 is treated with sodium alkyl mercaptide to obtain the desired compounds 3[3]. Although free Cl2 is the most common chlorinating agent,it is laborious to determine the accurate amount that has been absorbed,and the high reactivity of Cl2 always leads to side reactions. In connection with an our ongoing research project, we require an efficient and simple method for the synthesis of the compound 3.An improved synthesis process according to the following scheme is reported in this paper.

Abstract: The importance of the aliphatic α-organothio aldoxime compound 3 in the preparation of various pesticides is well established. Molecules comprising the α-organothio oxime moiety have been reported to exhibit insecticidal,nematocidal,miticidal activities.[1-2] In the synthesis of the compound 3,the chlorination of the corresponding aliphatic aldoxime 1 is the key step.In conventional methods, the aliphatic aldoxime 1 is chlorinated by chlorine,then the resulting hydroxime acid chloride 2 is treated with sodium alkyl mercaptide to obtain the desired compounds 3[3]. Although free Cl2 is the most common chlorinating agent,it is laborious to determine the accurate amount that has been absorbed,and the high reactivity of Cl2 always leads to side reactions. In connection with an our ongoing research project, we require an efficient and simple method for the synthesis of the compound 3.An improved synthesis process according to the following scheme is reported in this paper.

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