高等学校化学学报

高等学校化学学报 ›› 1998, Vol. 19 ›› Issue (S1): 323.

• Organometallic Chemistry • 上一篇    下一篇

Study on Reactivity of Five-co-ordinate Bicycloazastannoxides.IV. Michael Addition with Activated Olefins

Yang Xiao Ping1, Wang Ji Tao2   

  1. 1. Department of Chemistry, Liaoning Normal University, Dalian 116029;
    2. Deparment of Chemistry, Nankai University, Tianjin 300071
  • 出版日期:1998-12-31 发布日期:1998-12-31
  • 基金资助:
    This work was supported by the National Key Lab of the Elemento Organic Chemistry in China and the Science and Technology Foundation of Liaoning Province

Study on Reactivity of Five-co-ordinate Bicycloazastannoxides.IV. Michael Addition with Activated Olefins

Yang Xiao Ping1, Wang Ji Tao2   

  1. 1. Department of Chemistry, Liaoning Normal University, Dalian 116029;
    2. Deparment of Chemistry, Nankai University, Tianjin 300071
  • Online:1998-12-31 Published:1998-12-31
  • Supported by:
    This work was supported by the National Key Lab of the Elemento Organic Chemistry in China and the Science and Technology Foundation of Liaoning Province

PDF (PC)

摘要： In view of the large number of vitamin B6 related enzymes, one of the important features of the mechanism is the formation of an α-carbanion in the presence of a base catalyst[l,2]. The α-position may be the active site of the enzyme. As known, the most popular synthetic route consists of the conversion of a suitable derivation into a carbanion, followed by reaction with an electrophile. For five-co-ordinate bicycloazastannoxides, the coordination between a metal Sn atom and a Schifibase ligand increases the αCH acidity and stabilized the incipient carbanion[4]. But their electrophilic reactions on α-position have received less attention[3].

Abstract: In view of the large number of vitamin B6 related enzymes, one of the important features of the mechanism is the formation of an α-carbanion in the presence of a base catalyst[l,2]. The α-position may be the active site of the enzyme. As known, the most popular synthetic route consists of the conversion of a suitable derivation into a carbanion, followed by reaction with an electrophile. For five-co-ordinate bicycloazastannoxides, the coordination between a metal Sn atom and a Schifibase ligand increases the αCH acidity and stabilized the incipient carbanion[4]. But their electrophilic reactions on α-position have received less attention[3].

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