高等学校化学学报

高等学校化学学报 ›› 1998, Vol. 19 ›› Issue (S1): 31.

• Organic Synthesis Chemistry • 上一篇    下一篇

Misenine,a Novel Macrocyclic Alkaloid with an Unusual Skeleton from the Mediterranean Sponge Reniera sp

Yuewei Guo, Enrico Trivellone, Gennaro Scognamiglio, Guido Cimino   

  1. Istituto per la Chimica di MolecoJe di interesse Biologico-CNR, 1Via Toiano, 6-80072, Arco Felice(NA), Italy
  • 出版日期:1998-12-31 发布日期:1998-12-31

Misenine,a Novel Macrocyclic Alkaloid with an Unusual Skeleton from the Mediterranean Sponge Reniera sp

Yuewei Guo, Enrico Trivellone, Gennaro Scognamiglio, Guido Cimino   

  1. Istituto per la Chimica di MolecoJe di interesse Biologico-CNR, 1Via Toiano, 6-80072, Arco Felice(NA), Italy
  • Online:1998-12-31 Published:1998-12-31

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摘要： PolycycJic marine alkaloids containing 3-alkylpyridine or partially reduced 3-alkylpyridine as basic building blocks represent an emerging and intriguing group of bioactive natural products from marine sponges. Since halitoxin,2 the first example of this kind of alkaloid, was reported in 1978, many related alkaloids have been discovered from sponges of the order Haplosclerida. All of these alkaloids, in spite of formally exhibiting quite different frameworks, could biogeneticaliy derive from bis-3-alkylpyridine or reduced bis-3-alkylpyridine units. In the last decade, the knowledge of this fascinating group of compounds has increased remarkably. A recent review has exhaustively studied occurrence, distribution, plausible biogenetic origin and relatedness, as well as biological activities, of 3-alkylpyridine derived marine alkaloids.3

Abstract: PolycycJic marine alkaloids containing 3-alkylpyridine or partially reduced 3-alkylpyridine as basic building blocks represent an emerging and intriguing group of bioactive natural products from marine sponges. Since halitoxin,2 the first example of this kind of alkaloid, was reported in 1978, many related alkaloids have been discovered from sponges of the order Haplosclerida. All of these alkaloids, in spite of formally exhibiting quite different frameworks, could biogeneticaliy derive from bis-3-alkylpyridine or reduced bis-3-alkylpyridine units. In the last decade, the knowledge of this fascinating group of compounds has increased remarkably. A recent review has exhaustively studied occurrence, distribution, plausible biogenetic origin and relatedness, as well as biological activities, of 3-alkylpyridine derived marine alkaloids.3

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