高等学校化学学报

高等学校化学学报 ›› 1998, Vol. 19 ›› Issue (S1): 256.

• Organic Synthesis Chemistry • 上一篇    下一篇

Anionic Cyclization Approach to Hexahydrobenzo[b] furan-3-one and Hexahydro-1H-3-indolone:Application to Total Syntheses of Natural Products

沙晉康, 黃士榮, 黃建銘, 戴多士, 洪安威   

  1. Department of Chemistry, National Tsing Hua University, Hsinchu 300, Taiwan
  • 出版日期:1998-12-31 发布日期:1998-12-31

Anionic Cyclization Approach to Hexahydrobenzo[b] furan-3-one and Hexahydro-1H-3-indolone:Application to Total Syntheses of Natural Products

Chin-Kang Sha, Shih-Jung Huang, Jainn-Ming Huang, Danialdoss S., An-Wei Hong   

  1. Department of Chemistry, National Tsing Hua University, Hsinchu 300, Taiwan
  • Online:1998-12-31 Published:1998-12-31

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摘要： Hexahydrobenzo[b]furan-3-one(3) and hexahydro-1H-3-indolone (4) are potentially useful intermediates for total synthesis of natural products, such as the hexahydrobenzofuran unit (5) of avermectins and pancracine (6). Anionic cyclization approach toward (3) and (4) have been developed. Their application to the total synthesis of (5) and (6) will be presented.

Abstract: Hexahydrobenzo[b]furan-3-one(3) and hexahydro-1H-3-indolone (4) are potentially useful intermediates for total synthesis of natural products, such as the hexahydrobenzofuran unit (5) of avermectins and pancracine (6). Anionic cyclization approach toward (3) and (4) have been developed. Their application to the total synthesis of (5) and (6) will be presented.

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