高等学校化学学报

高等学校化学学报 ›› 1998, Vol. 19 ›› Issue (S1): 253.

• Organic Synthesis Chemistry • 上一篇    下一篇

Enantiospecitic Synthesis of 1N-Sulfa-3-Nitro-4-(l,2-Acetonide)-2-Azetidmones

Henguang Li, Rugang Xie, Tong Wua, Jian Hu, Yiemin Lei   

  1. 1. Sichuan Industrial Institute of Antibiotics 610051, Chendu, Sichuan;
    2. Department of Chemistry, Sichuan University 610064, Chendu, Sichuan
  • 出版日期:1998-12-31 发布日期:1998-12-31
  • 基金资助:
    This research program has been supported by The National Fund of Novel Medicine Research

Enantiospecitic Synthesis of 1N-Sulfa-3-Nitro-4-(l,2-Acetonide)-2-Azetidmones

Henguang Li, Rugang Xie, Tong Wua, Jian Hu, Yiemin Lei   

  1. 1. Sichuan Industrial Institute of Antibiotics 610051, Chendu, Sichuan;
    2. Department of Chemistry, Sichuan University 610064, Chendu, Sichuan
  • Online:1998-12-31 Published:1998-12-31
  • Supported by:
    This research program has been supported by The National Fund of Novel Medicine Research

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摘要： β-lactams are not only to be excellent antibiotics used widely in clinic treatment of many bacteria infected disease but also express some other potential physiology activities, such as antifungal, enzyme inhibition, antineoplastic agent,hypocholesterolemic agent1). In fact,there are much more methods in the synthesis of derivatives β-lactam2). In the course of our synthetic studies towards a series novel β-lactam analogs we have required a variety of higher optic purity key intermediates. Hear we would like to report the quite easy and versatile way by the cycloaddition of chiral alkene and chlorosulfonyl isocyanate (CSI) to produce those importent mono-ring compounds3).

Abstract: β-lactams are not only to be excellent antibiotics used widely in clinic treatment of many bacteria infected disease but also express some other potential physiology activities, such as antifungal, enzyme inhibition, antineoplastic agent,hypocholesterolemic agent1). In fact,there are much more methods in the synthesis of derivatives β-lactam2). In the course of our synthetic studies towards a series novel β-lactam analogs we have required a variety of higher optic purity key intermediates. Hear we would like to report the quite easy and versatile way by the cycloaddition of chiral alkene and chlorosulfonyl isocyanate (CSI) to produce those importent mono-ring compounds3).

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