高等学校化学学报

高等学校化学学报 ›› 1998, Vol. 19 ›› Issue (S1): 242.

• Organic Synthesis Chemistry • 上一篇    下一篇

SYNTHESIS OF MESO-TETRA(SUBSTITUTED PHENYL) PORPHIN NITROGEN MUSTARDS WITH POYENTIAL ANTI-TUMOR ACTIVITIES

Zhi-Long Chen, Jin-Rong Chen, Wei-Qin Wan, De-Yu Xu   

  1. Institute of Pharmaceutical Chemistry, Second Military Medical University, 800 Xiang Yin Road, Shanghai 200433
  • 出版日期:1998-12-31 发布日期:1998-12-31

SYNTHESIS OF MESO-TETRA(SUBSTITUTED PHENYL) PORPHIN NITROGEN MUSTARDS WITH POYENTIAL ANTI-TUMOR ACTIVITIES

Zhi-Long Chen, Jin-Rong Chen, Wei-Qin Wan, De-Yu Xu   

  1. Institute of Pharmaceutical Chemistry, Second Military Medical University, 800 Xiang Yin Road, Shanghai 200433
  • Online:1998-12-31 Published:1998-12-31

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摘要： With the development of laser medicine and technology in light-conducted fiber and endoscope, photodynamic therapy (PDT) obtained regulatory approvals in the United States and elsewhere to cure malignent tumors in skin,esophagi, bronchi and bladder. PDT is based on the ability of some porphyrins and porphyrin-like chromophores to be accumulated selectivity in tumor tissues; tumor necrosis can be obtained by irradiation of the neoplastic area with light of the appropriate wavelength. Until now a few thousand patients have been successfully treated by PDT worldwide. Hematoporphyrin derivatives (HpD) is a complex mixture of porphins which could retain in skin and the cutaneous photosensitivity lasting for 6 to 8 weeks after the treatment was resulted in.To alleviate patient's suffering from damages of normal tissues in chemotherapy and eliminate cutaneous photosensitivity as well as enhance the depth of tumor necrosis, we synthesized a series of new compounds by introducing the antitumor group nitrogen mustard into the periphery of meso-tetraphenyl porphins.

Abstract: With the development of laser medicine and technology in light-conducted fiber and endoscope, photodynamic therapy (PDT) obtained regulatory approvals in the United States and elsewhere to cure malignent tumors in skin,esophagi, bronchi and bladder. PDT is based on the ability of some porphyrins and porphyrin-like chromophores to be accumulated selectivity in tumor tissues; tumor necrosis can be obtained by irradiation of the neoplastic area with light of the appropriate wavelength. Until now a few thousand patients have been successfully treated by PDT worldwide. Hematoporphyrin derivatives (HpD) is a complex mixture of porphins which could retain in skin and the cutaneous photosensitivity lasting for 6 to 8 weeks after the treatment was resulted in.To alleviate patient's suffering from damages of normal tissues in chemotherapy and eliminate cutaneous photosensitivity as well as enhance the depth of tumor necrosis, we synthesized a series of new compounds by introducing the antitumor group nitrogen mustard into the periphery of meso-tetraphenyl porphins.

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