高等学校化学学报 ›› 1998, Vol. 19 ›› Issue (S1): 236.
• Organic Synthesis Chemistry • 上一篇 下一篇
Bo Han, Yu Chen, Yu-Fen Zhao
Bo Han, Yu Chen, Yu-Fen Zhao
摘要: The report of Lienhard and Secemski1 on the potent inhibition of adenylate kinase by the dinucleoside analogue of adenosine, P1, P5-di(adenosine-5')pentaphosphate (Ap5A), stimulated our synthesis of Nα, Nε-bis(O-deoxythymin-3'yl O-isopropyl phosphoryl) lysine methyl ester (BTPL) as a potential inhibitor of the metabolic pathway concerned with the biosynthesis of DNA-thymine. To our knowledge, it's the first example of lysine linked two nucleotides through P-N bond.
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