高等学校化学学报 ›› 1998, Vol. 19 ›› Issue (S1): 236.

• Organic Synthesis Chemistry • 上一篇    下一篇

Synthesis of Nα, Nε-Bis(O-deoxythymin-3'-ylO-isopropyl phosphoryl) Lysine Methyl Ester

Bo Han, Yu Chen, Yu-Fen Zhao   

  1. Bioorganic Phosphorus Chemistry Laboratory, Department of Chemistry, Tsinghua University, Beijing 100084
  • 出版日期:1998-12-31 发布日期:1998-12-31

Synthesis of Nα, Nε-Bis(O-deoxythymin-3'-ylO-isopropyl phosphoryl) Lysine Methyl Ester

Bo Han, Yu Chen, Yu-Fen Zhao   

  1. Bioorganic Phosphorus Chemistry Laboratory, Department of Chemistry, Tsinghua University, Beijing 100084
  • Online:1998-12-31 Published:1998-12-31

摘要: The report of Lienhard and Secemski1 on the potent inhibition of adenylate kinase by the dinucleoside analogue of adenosine, P1, P5-di(adenosine-5')pentaphosphate (Ap5A), stimulated our synthesis of Nα, Nε-bis(O-deoxythymin-3'yl O-isopropyl phosphoryl) lysine methyl ester (BTPL) as a potential inhibitor of the metabolic pathway concerned with the biosynthesis of DNA-thymine. To our knowledge, it's the first example of lysine linked two nucleotides through P-N bond.

Abstract: The report of Lienhard and Secemski1 on the potent inhibition of adenylate kinase by the dinucleoside analogue of adenosine, P1, P5-di(adenosine-5')pentaphosphate (Ap5A), stimulated our synthesis of Nα, Nε-bis(O-deoxythymin-3'yl O-isopropyl phosphoryl) lysine methyl ester (BTPL) as a potential inhibitor of the metabolic pathway concerned with the biosynthesis of DNA-thymine. To our knowledge, it's the first example of lysine linked two nucleotides through P-N bond.

TrendMD: