高等学校化学学报 ›› 1998, Vol. 19 ›› Issue (S1): 232.
• Organic Synthesis Chemistry • 上一篇 下一篇
Hegui Gong, Zhaolong Li, Hua Fu, Yufen Zhao
Hegui Gong, Zhaolong Li, Hua Fu, Yufen Zhao
摘要: It was discovered that polypeptides were formed by self-assembly of N,O-bis(trimethylsilyl)amino acids with the assistance of O-phenylene phosphorochloridate.[1] There were three steps involved in the self organization reactions, the activation of amino acid, the elongation of peptide chain and the termination of the chain reaction,among which the activation of amino acid -the formation of imino (alkyl)acetoxyphosphoranes was the key step. The formation process of the penta-coordinated phosphorus intermediates was showed in scheme 1.[2,3,4] Through further studies of the mechanism of self-assembly reaction, it was found that carbonyl groups of the intermediates attacked by the neuclophilic groups were direct reson of the formation of peptides. However, the peptides in the solution were very difficult to be separated and analyzed.
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