高等学校化学学报 ›› 1998, Vol. 19 ›› Issue (S1): 224.

• Organic Synthesis Chemistry • 上一篇    下一篇

Studies on Bioactive Selenium-containing Organophosphorus Compounds: Synthesis of 1-Aminoalkanephosphonate Derivatives of Benzisoselenazolone and Their Antitumor Activity

Jia Zhou, Ru-Yu Chen   

  1. Institute of Elemento-Organic Chemistry, The State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin 300071
  • 出版日期:1998-12-31 发布日期:1998-12-31
  • 基金资助:
    National Natural Science Foundation of China for financial support

Studies on Bioactive Selenium-containing Organophosphorus Compounds: Synthesis of 1-Aminoalkanephosphonate Derivatives of Benzisoselenazolone and Their Antitumor Activity

Jia Zhou, Ru-Yu Chen   

  1. Institute of Elemento-Organic Chemistry, The State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin 300071
  • Online:1998-12-31 Published:1998-12-31
  • Supported by:
    National Natural Science Foundation of China for financial support

摘要: Various selenium-containing compounds are widely used as reagents and intermediates in organic synthesis.1 In recent years biologically active organoselenium compounds have begun to attract considerable interest due to their unique and diverse potential pharmacological importance such as broad spectrum antitumor and antiviral activities, and some of them are even many times more active than their thio analogues.2,3 It was found that benzisoselenazolones[e.g.,Ebselen, 2-phenyl-1,2-benzisoselenazol-3(2H)-one], are effective for the treatment of diseases caused by cell damage owing to increased formation of active oxygen metabolites4 and these pharmacological effects are mainly attributed to the glutathione peroxidase (GSH-Px) like properties.5

Abstract: Various selenium-containing compounds are widely used as reagents and intermediates in organic synthesis.1 In recent years biologically active organoselenium compounds have begun to attract considerable interest due to their unique and diverse potential pharmacological importance such as broad spectrum antitumor and antiviral activities, and some of them are even many times more active than their thio analogues.2,3 It was found that benzisoselenazolones[e.g.,Ebselen, 2-phenyl-1,2-benzisoselenazol-3(2H)-one], are effective for the treatment of diseases caused by cell damage owing to increased formation of active oxygen metabolites4 and these pharmacological effects are mainly attributed to the glutathione peroxidase (GSH-Px) like properties.5

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