高等学校化学学报

高等学校化学学报 ›› 1998, Vol. 19 ›› Issue (S1): 216.

• Organic Synthesis Chemistry • 上一篇    下一篇

“Approximation”-Novel Methodology to Identify the Active Components from Compounds Library

YU Ai-Ming, TAN Hui-Fen, YANG Hua-Zheng, ZHANG Zheng-Pu   

  1. 1. State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin 300071;
    2. State Key Laboratory of Functional Polymeric Materials for Adsorption and Separation, Nankai University, Tianjin 300071
  • 出版日期:1998-12-31 发布日期:1998-12-31
  • 基金资助:
    This project is supported by the NSFC

“Approximation”-Novel Methodology to Identify the Active Components from Compounds Library

YU Ai-Ming, TAN Hui-Fen, YANG Hua-Zheng, ZHANG Zheng-Pu   

  1. 1. State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin 300071;
    2. State Key Laboratory of Functional Polymeric Materials for Adsorption and Separation, Nankai University, Tianjin 300071
  • Online:1998-12-31 Published:1998-12-31
  • Supported by:
    This project is supported by the NSFC

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摘要： Combinatorial chemistry has been regarded as one of the most efficient method in medicinal chemistry. Identification of active compounds from compounds library is one of the main steps of combinatorial chemistry. Many approaches have been developed for this purpose, such as deconvolution[1] positional scanning[2], SURF[3],orthogonal library[4], indexed library[5], core molecule library[6] etc. Actually, all the methods are based on the rule of determining the structure of "Active Components" or "Active Compounds"(AC) from "Active Compounds Library"(ACL) by identifying "Active Building Blocks"(ABB). In this way, more efficient method named "Approximation" was developed by reducing the ABB by half in every steps, which was depicted as below by taking "8ҿ8" library as a example.

Abstract: Combinatorial chemistry has been regarded as one of the most efficient method in medicinal chemistry. Identification of active compounds from compounds library is one of the main steps of combinatorial chemistry. Many approaches have been developed for this purpose, such as deconvolution[1] positional scanning[2], SURF[3],orthogonal library[4], indexed library[5], core molecule library[6] etc. Actually, all the methods are based on the rule of determining the structure of "Active Components" or "Active Compounds"(AC) from "Active Compounds Library"(ACL) by identifying "Active Building Blocks"(ABB). In this way, more efficient method named "Approximation" was developed by reducing the ABB by half in every steps, which was depicted as below by taking "8ҿ8" library as a example.

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