高等学校化学学报

高等学校化学学报 ›› 1998, Vol. 19 ›› Issue (S1): 202.

• Organic Synthesis Chemistry • 上一篇    下一篇

Design, Synthesis and Activities of Cyanoacrylates Photosystem Ⅱ Inhibitors Basen on D1 Protein

Huayin Liu, Huifen Tan, Huazheng Yang   

  1. Institute of Elemento-Organic Chemistry, National Key Laboratory of Elemento-Organic Chemistry Nankai University, Tianjin 300071
  • 出版日期:1998-12-31 发布日期:1998-12-31
  • 基金资助:
    This study was supported by grants from the Youth Science Fundation of China (No: 29702006)

Design, Synthesis and Activities of Cyanoacrylates Photosystem Ⅱ Inhibitors Basen on D1 Protein

Huayin Liu, Huifen Tan, Huazheng Yang   

  1. Institute of Elemento-Organic Chemistry, National Key Laboratory of Elemento-Organic Chemistry Nankai University, Tianjin 300071
  • Online:1998-12-31 Published:1998-12-31
  • Supported by:
    This study was supported by grants from the Youth Science Fundation of China (No: 29702006)

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摘要： Photosynthesis is a particularly attractive target for the design of potential commercial herbicides. Since photosynthesis is a mechanism that occurs in plants only, all inhibitors are in theory nontoxic to mammals. A large number of inhibitors, including ureas, triazines and phenols etc., are known to block photosystem Ⅱ by displacing plastoquinone from the QB-binding niche of the D1 protein in the reaction center. The X-ray study by Deisenhofer et al. of the photosystem of Rps viridis was an important milestone, since it initiated molecular modeling studies in academia and instustry in order to find new PS Ⅱ inhibitors.

Abstract: Photosynthesis is a particularly attractive target for the design of potential commercial herbicides. Since photosynthesis is a mechanism that occurs in plants only, all inhibitors are in theory nontoxic to mammals. A large number of inhibitors, including ureas, triazines and phenols etc., are known to block photosystem Ⅱ by displacing plastoquinone from the QB-binding niche of the D1 protein in the reaction center. The X-ray study by Deisenhofer et al. of the photosystem of Rps viridis was an important milestone, since it initiated molecular modeling studies in academia and instustry in order to find new PS Ⅱ inhibitors.

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