高等学校化学学报

高等学校化学学报 ›› 1998, Vol. 19 ›› Issue (S1): 198.

• Organic Synthesis Chemistry • 上一篇    下一篇

Combinatorial Synthesis of O-Pyrimidinyl Substituted Methyl-α-D-Glucopyranosides

Yun Liao1, Zheng-Ming Li1, Henry N. C. Wong2   

  1. 1. State Laboratory of Elemento-Organic Chemistry;Elemento-Organic Chemistry Institute, Nankai University, Tianjin 300071;
    2. Department of Chemistry, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong
  • 出版日期:1998-12-31 发布日期:1998-12-31

Combinatorial Synthesis of O-Pyrimidinyl Substituted Methyl-α-D-Glucopyranosides

Yun Liao1, Zheng-Ming Li1, Henry N. C. Wong2   

  1. 1. State Laboratory of Elemento-Organic Chemistry;Elemento-Organic Chemistry Institute, Nankai University, Tianjin 300071;
    2. Department of Chemistry, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong
  • Online:1998-12-31 Published:1998-12-31

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摘要： Within last decade, many pyrimidinyl oxy substituted alcohols, aldehydes and carboxylic derivatives had been found with prominent bio-activities such as high herbicidal activities with wide spectrum. After extensively study of the relationship between structures and bioactivities, A brand-new scaffold combining both pyrimidinyl and glucoside moieties was designed and other building blocks were further introduced with the help of polymer-supported regioselective protecting groups. As shown below, a combinatorial synthesis was carried out by applying "mix-split" method to produce the following series of small compounds libraries both in solid-phase and liquid phase.

Abstract: Within last decade, many pyrimidinyl oxy substituted alcohols, aldehydes and carboxylic derivatives had been found with prominent bio-activities such as high herbicidal activities with wide spectrum. After extensively study of the relationship between structures and bioactivities, A brand-new scaffold combining both pyrimidinyl and glucoside moieties was designed and other building blocks were further introduced with the help of polymer-supported regioselective protecting groups. As shown below, a combinatorial synthesis was carried out by applying "mix-split" method to produce the following series of small compounds libraries both in solid-phase and liquid phase.

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