高等学校化学学报

高等学校化学学报 ›› 1998, Vol. 19 ›› Issue (S1): 188.

• Organic Synthesis Chemistry • 上一篇    下一篇

Synthesis of 1-(2'-Alkylthioethoxy)methyl Uracil and Thymine Derivatives

Xuejun Liu, Ruyu Chen   

  1. Institute of Elemento-Organic Chemistry, Nakai University, Tianjin 300071
  • 出版日期:1998-12-31 发布日期:1998-12-31
  • 基金资助:
    Project 29772018 was supported by National Natruarl Science Foundation of China

Synthesis of 1-(2'-Alkylthioethoxy)methyl Uracil and Thymine Derivatives

Xuejun Liu, Ruyu Chen   

  1. Institute of Elemento-Organic Chemistry, Nakai University, Tianjin 300071
  • Online:1998-12-31 Published:1998-12-31
  • Supported by:
    Project 29772018 was supported by National Natruarl Science Foundation of China

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摘要： There is a serious need for compounds that are effective in the treatment of cancer and virus (HIV. Human Immunodeficiency Virus,etc.). Among the large number of nucleoside analogs which have been synthesized and evaluated(1-2) recently several 5'-alkylthio nucleosides have been reported to exhibit good antitumor and antiviral activities(3-4). Their anticancer mechanism involves blocking cancer cell proliferation and inhibiting the cytoplasmic isozyme(C-TK)(5), one isozyme of thymine kinase, which predominates in human tumor cell lines(6). As we know, many acylic nucleoside analogs have appeared good biological activities(7). It is reported that they can also act on some thymine kinases and end up the propagation of the viral DNA chain(8).

Abstract: There is a serious need for compounds that are effective in the treatment of cancer and virus (HIV. Human Immunodeficiency Virus,etc.). Among the large number of nucleoside analogs which have been synthesized and evaluated(1-2) recently several 5'-alkylthio nucleosides have been reported to exhibit good antitumor and antiviral activities(3-4). Their anticancer mechanism involves blocking cancer cell proliferation and inhibiting the cytoplasmic isozyme(C-TK)(5), one isozyme of thymine kinase, which predominates in human tumor cell lines(6). As we know, many acylic nucleoside analogs have appeared good biological activities(7). It is reported that they can also act on some thymine kinases and end up the propagation of the viral DNA chain(8).

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