高等学校化学学报

高等学校化学学报 ›› 1998, Vol. 19 ›› Issue (S1): 184.

• Organic Synthesis Chemistry • 上一篇    下一篇

A Preliminary Study of the Reaction of 5-Pyrazole Hydrazide and Malononitrile Derivatives

CHEN Hansong, LI Zhengming   

  1. Research Institute of Elemento-Organic Chemistry, Nankai University, Tianjin 300071
  • 出版日期:1998-12-31 发布日期:1998-12-31
  • 基金资助:
    Supported by State Key Laboratory of Elemento-Organic Chemistry

A Preliminary Study of the Reaction of 5-Pyrazole Hydrazide and Malononitrile Derivatives

CHEN Hansong, LI Zhengming   

  1. Research Institute of Elemento-Organic Chemistry, Nankai University, Tianjin 300071
  • Online:1998-12-31 Published:1998-12-31
  • Supported by:
    Supported by State Key Laboratory of Elemento-Organic Chemistry

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摘要： The reaction of alkyl hydrazine with ethoxymethylenemalononitrile (EMM) is a routine reaction, the corresponding product, pyrazole ring, will be obtained usually, For example, p-chlorophenylhydrazine with EMM[1].However, 5-pyrazole hydrazide[2] is different. When they reacted with EMM on condition that either reflux or room temperature, l,2-bis(5-pyrazolylcarbonyl)hydrazine (3),the abnormal products, instead of 5-amino-4-cyano-1-pyrazolylcarbonyl-1H-pyrazole(4) were formed (see Scheme 1).

Abstract: The reaction of alkyl hydrazine with ethoxymethylenemalononitrile (EMM) is a routine reaction, the corresponding product, pyrazole ring, will be obtained usually, For example, p-chlorophenylhydrazine with EMM[1].However, 5-pyrazole hydrazide[2] is different. When they reacted with EMM on condition that either reflux or room temperature, l,2-bis(5-pyrazolylcarbonyl)hydrazine (3),the abnormal products, instead of 5-amino-4-cyano-1-pyrazolylcarbonyl-1H-pyrazole(4) were formed (see Scheme 1).

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