高等学校化学学报 ›› 1998, Vol. 19 ›› Issue (S1): 174.

• Organic Synthesis Chemistry • 上一篇    下一篇

Synthesis of a New Conformational Constrained Cyclic Peptide Containing Pyridine and Cystine

Hai Huang, Jinpei Cheng, Xiaohu Gao, Linjing Mu, Xubo Hu   

  1. Department of Chemistry, Nankai University, Tianjin 300071
  • 出版日期:1998-12-31 发布日期:1998-12-31
  • 通讯作者: Jinpei Cheng
  • 基金资助:
    This work was supported by grants from NSFC and ministry of education of China

Synthesis of a New Conformational Constrained Cyclic Peptide Containing Pyridine and Cystine

Hai Huang, Jinpei Cheng, Xiaohu Gao, Linjing Mu, Xubo Hu   

  1. Department of Chemistry, Nankai University, Tianjin 300071
  • Online:1998-12-31 Published:1998-12-31
  • Contact: Jinpei Cheng
  • Supported by:
    This work was supported by grants from NSFC and ministry of education of China

摘要: As a class of peptide series, cyclic peptides have aroused great interest in the past few years. They are found to possess many biological functions such as membrane transport, antibiotics, toxins, hormones and so on1. Similar to the well-known macrocyclic compounds such as the crown ethers, cyclodextrins and calix arenes, they are found to be good host molecules as well in recognizing ions and small molecules2. Recently, much progress has been made on the synthesis of conformational constrained cyclopeptides in this laboratory. Because introducing a rigid subunit to the backbone of cyclic peptides can largely reduce their, conformational complications and enhance their recognition affinities, Ranganathan3 and Cheng4,5 and co-workers have synthesized some series of cyclic peptides analogues containing adamantane and benzene, respectively. These pseudocyclopeptides all showed good affinity to form complexes with ions and small molecules.

Abstract: As a class of peptide series, cyclic peptides have aroused great interest in the past few years. They are found to possess many biological functions such as membrane transport, antibiotics, toxins, hormones and so on1. Similar to the well-known macrocyclic compounds such as the crown ethers, cyclodextrins and calix arenes, they are found to be good host molecules as well in recognizing ions and small molecules2. Recently, much progress has been made on the synthesis of conformational constrained cyclopeptides in this laboratory. Because introducing a rigid subunit to the backbone of cyclic peptides can largely reduce their, conformational complications and enhance their recognition affinities, Ranganathan3 and Cheng4,5 and co-workers have synthesized some series of cyclic peptides analogues containing adamantane and benzene, respectively. These pseudocyclopeptides all showed good affinity to form complexes with ions and small molecules.

TrendMD: