高等学校化学学报

高等学校化学学报 ›› 1998, Vol. 19 ›› Issue (S1): 168.

• Organic Synthesis Chemistry • 上一篇    下一篇

Total Synthesis and Stereochemistry of 13-Hydroxy-α-eudesmol

Yonggang Chen, Zhaoming Xiong, Gang Zhou, Lijun Liu, Yulin Li   

  1. National Laboratory of Applied Organic Chemistry and Institute of Organic Chemistry, Lanzhou University, Lanzhou 730000
  • 出版日期:1998-12-31 发布日期:1998-12-31
  • 基金资助:
    National Natural Science Foundation of China (Grant No. 29732060)

Total Synthesis and Stereochemistry of 13-Hydroxy-α-eudesmol

Yonggang Chen, Zhaoming Xiong, Gang Zhou, Lijun Liu, Yulin Li   

  1. National Laboratory of Applied Organic Chemistry and Institute of Organic Chemistry, Lanzhou University, Lanzhou 730000
  • Online:1998-12-31 Published:1998-12-31
  • Supported by:
    National Natural Science Foundation of China (Grant No. 29732060)

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摘要： Recently, 13-hydroxy-α-eudesmol 1a was first isolated from C. uncata Cunn. by King and Robinson et aL and its structure was determined by high field NMR techniques, however, the absolute configuration of C-11 remained unsolved. Herein, we report the first total synthesis and determination of the stereochemistry of 13-hydroxy-α-eudesmol. In our synthesis (+)-α-selinene has also been accomplished.

Abstract: Recently, 13-hydroxy-α-eudesmol 1a was first isolated from C. uncata Cunn. by King and Robinson et aL and its structure was determined by high field NMR techniques, however, the absolute configuration of C-11 remained unsolved. Herein, we report the first total synthesis and determination of the stereochemistry of 13-hydroxy-α-eudesmol. In our synthesis (+)-α-selinene has also been accomplished.

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