高等学校化学学报

高等学校化学学报 ›› 1998, Vol. 19 ›› Issue (S1): 154.

• Organic Synthesis Chemistry • 上一篇    下一篇

The Total Synthesis of (±)-13-Hydroxyneocembrene

Yacheng Xing1, Wen Cen1, Ying Li2, Jiong Lan2, Yulin Li2   

  1. 1. Department of Chemistry, Qingdao University, Qingdao 266071;
    2. National Laboratory of Applied Organic Chemistry and Institute of Organic Chemistry, Lanzhou University, Lanzhou 730000
  • 出版日期:1998-12-31 发布日期:1998-12-31
  • 基金资助:
    This work was financially supported by the National Nature Science Foundation of China (Grant NO.29672015)

The Total Synthesis of (±)-13-Hydroxyneocembrene

Yacheng Xing1, Wen Cen1, Ying Li2, Jiong Lan2, Yulin Li2   

  1. 1. Department of Chemistry, Qingdao University, Qingdao 266071;
    2. National Laboratory of Applied Organic Chemistry and Institute of Organic Chemistry, Lanzhou University, Lanzhou 730000
  • Online:1998-12-31 Published:1998-12-31
  • Supported by:
    This work was financially supported by the National Nature Science Foundation of China (Grant NO.29672015)

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摘要： (13S)-hydroxyneocembrene(18), a cembranoid which was isolated in 1988 from soft coral Sarcophyton trocheliophorum1, has been shown to be an effective inductor of the release of labeled glucose from the lecithincholesterol liposomes and have cytostatic activities2. The geometrical structure and absolute configuration of 18 have been defined to be 1S, 2E, 7E, 11E, 13S. Herein, we report the total synthesis of (±)-13hydroxyneocembrene(18).

Abstract: (13S)-hydroxyneocembrene(18), a cembranoid which was isolated in 1988 from soft coral Sarcophyton trocheliophorum1, has been shown to be an effective inductor of the release of labeled glucose from the lecithincholesterol liposomes and have cytostatic activities2. The geometrical structure and absolute configuration of 18 have been defined to be 1S, 2E, 7E, 11E, 13S. Herein, we report the total synthesis of (±)-13hydroxyneocembrene(18).

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