高等学校化学学报

高等学校化学学报 ›› 1998, Vol. 19 ›› Issue (S1): 150.

• Organic Synthesis Chemistry • 上一篇    下一篇

Regioselective Synthesis of Two Novel 2-geranyloxyacetophenones

Haifu GUO, Chusheng HUANG, Wenfei TAN, Yulin LI   

  1. National Laboratory of Applied Organic Chemistry and Institute of Organic Chemistry, Lanzhou University, Lanzhou 730000
  • 出版日期:1998-12-31 发布日期:1998-12-31
  • 通讯作者: Haifu GUO
  • 基金资助:
    Supported by the National Natural Science Foundation of China and the Natural Science Foundation of Guangxi Province

Regioselective Synthesis of Two Novel 2-geranyloxyacetophenones

Haifu GUO, Chusheng HUANG, Wenfei TAN, Yulin LI   

  1. National Laboratory of Applied Organic Chemistry and Institute of Organic Chemistry, Lanzhou University, Lanzhou 730000
  • Online:1998-12-31 Published:1998-12-31
  • Contact: Haifu GUO
  • Supported by:
    Supported by the National Natural Science Foundation of China and the Natural Science Foundation of Guangxi Province

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被引次数

5

摘要： The phenols containing geranyl units1 are a large group of interesting natural products exhibited many physiological actions as antiflammatory, antibacterial and antioxidative activities2. Two novel acetophenones 1 and 2 were recently isolated from the fruits of Evodia merrillii, a small folk medicinal tree widely distributed in Taiwan3. Their structures were elucidated as 2-(1'-geranyl)-4,6-dihydroxyacetophenone 1 and 2-(1'-geranyloxy)-2,6,α-trihydroxyacetophenone 2 by means of spectroscopic data. So far as we know, the total synthesis of them have not been reported yet. Herein, we wish to report the first total synthesis of 1 and 2,starting from 2,4,6-trihydroxyacetophenone.

Abstract: The phenols containing geranyl units1 are a large group of interesting natural products exhibited many physiological actions as antiflammatory, antibacterial and antioxidative activities2. Two novel acetophenones 1 and 2 were recently isolated from the fruits of Evodia merrillii, a small folk medicinal tree widely distributed in Taiwan3. Their structures were elucidated as 2-(1'-geranyl)-4,6-dihydroxyacetophenone 1 and 2-(1'-geranyloxy)-2,6,α-trihydroxyacetophenone 2 by means of spectroscopic data. So far as we know, the total synthesis of them have not been reported yet. Herein, we wish to report the first total synthesis of 1 and 2,starting from 2,4,6-trihydroxyacetophenone.

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