高等学校化学学报

高等学校化学学报 ›› 1998, Vol. 19 ›› Issue (S1): 14.

• Plenary, Keynote and Invited Lectures • 上一篇    下一篇

Theoretical Studies of β-Peptide Models

Yun-Dong Wu, De-Ping Wang   

  1. Department of Chemistry, the Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong
  • 出版日期:1998-12-31 发布日期:1998-12-31

Theoretical Studies of β-Peptide Models

Yun-Dong Wu, De-Ping Wang   

  1. Department of Chemistry, the Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong
  • Online:1998-12-31 Published:1998-12-31

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摘要： Recently, the β-peptides, which consist entirely of β-amino acids instead of α-amino acids, have received intensive attention because of their interesting secondary structures.1-3 Depending upon side chain substitution pattern, β-sheets, 14-helices, and 12-helices all have been observed.1 Due to great variety of substitution patterns,the easiness of formation of secondary structures with even 4-6 residues compared to about 15 for natural peptides,and ready formation of cyclic compounds that stack into tube structures,4 β-peptides have generated great excitement. In addition,β-amino acids also frequently occur in natural products, especially cyclic peptides. It has been found that β-amino acids have excellent stability toward proteases. Therefore, they have wide applications in drug development.6

Abstract: Recently, the β-peptides, which consist entirely of β-amino acids instead of α-amino acids, have received intensive attention because of their interesting secondary structures.1-3 Depending upon side chain substitution pattern, β-sheets, 14-helices, and 12-helices all have been observed.1 Due to great variety of substitution patterns,the easiness of formation of secondary structures with even 4-6 residues compared to about 15 for natural peptides,and ready formation of cyclic compounds that stack into tube structures,4 β-peptides have generated great excitement. In addition,β-amino acids also frequently occur in natural products, especially cyclic peptides. It has been found that β-amino acids have excellent stability toward proteases. Therefore, they have wide applications in drug development.6

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