高等学校化学学报

高等学校化学学报 ›› 1998, Vol. 19 ›› Issue (S1): 133.

• Organic Synthesis Chemistry • 上一篇    下一篇

ACCELERATED APPROACH TO THE SYNTHESIS OF METHOXYCARBONYL-TERMINATED POLYETHER DENDRIMERS

LI Xiao-Hong, CAO Xiao-Ping, ZHOU Wei-Gang, NIE Kai-Sheng   

  1. National Laboratory of Applied Organic Chemistry, Department of Chemistry, Lanzhou University, Lanzhou 730000
  • 出版日期:1998-12-31 发布日期:1998-12-31
  • 基金资助:
    This project was supported by the returned student studying abroad fuondation of the State Education Committee of China and the NSF of Gansu province (ZQ-97-001)

ACCELERATED APPROACH TO THE SYNTHESIS OF METHOXYCARBONYL-TERMINATED POLYETHER DENDRIMERS

LI Xiao-Hong, CAO Xiao-Ping, ZHOU Wei-Gang, NIE Kai-Sheng   

  1. National Laboratory of Applied Organic Chemistry, Department of Chemistry, Lanzhou University, Lanzhou 730000
  • Online:1998-12-31 Published:1998-12-31
  • Supported by:
    This project was supported by the returned student studying abroad fuondation of the State Education Committee of China and the NSF of Gansu province (ZQ-97-001)

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被引次数

23

摘要： Dendrimers are macromolecules that radiate out from a central core, with the number of branch points on a given arm increasing exponentially from the core to the periphery.1 Because of their novel properties, dendrimers have found many uses, including as unimolecular micelles, novel amphiphiles, and complexation agents.2 These and other applications will benefit from more efficient methods of dendrimer preparation. The synthesis of dendrimer can be divided into both the divergent approach developed by Tomalia3 and Newkome,4 and the convergent method of Frechet.5 The convergent method was adopted in the synthesis of our target methoxycarbonyl-terminated polyether dendrimers. This method has the advantage over the divergent one in that the number of reaction in each step is restricted to a fixed small number irrespective of dendrimer generation, therefore completion of the reaction in each step can be controlled and monitored and large excess of reagent is not required even in the preparation of higher generation dendrimers.

Abstract: Dendrimers are macromolecules that radiate out from a central core, with the number of branch points on a given arm increasing exponentially from the core to the periphery.1 Because of their novel properties, dendrimers have found many uses, including as unimolecular micelles, novel amphiphiles, and complexation agents.2 These and other applications will benefit from more efficient methods of dendrimer preparation. The synthesis of dendrimer can be divided into both the divergent approach developed by Tomalia3 and Newkome,4 and the convergent method of Frechet.5 The convergent method was adopted in the synthesis of our target methoxycarbonyl-terminated polyether dendrimers. This method has the advantage over the divergent one in that the number of reaction in each step is restricted to a fixed small number irrespective of dendrimer generation, therefore completion of the reaction in each step can be controlled and monitored and large excess of reagent is not required even in the preparation of higher generation dendrimers.

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