高等学校化学学报 ›› 1998, Vol. 19 ›› Issue (S1): 131.
• Organic Synthesis Chemistry • 上一篇 下一篇
ShuXin LI, WenXiang HU, HuaTang XU, JianYing WANG, Shengian TAN
ShuXin LI, WenXiang HU, HuaTang XU, JianYing WANG, Shengian TAN
摘要: 4-Alkyl derivatives of 2,6,7-trioxa-1-phosphabicyclo[2.2.2] octanes are extensively used for spectroscopic studies and are candidates for use as flame retardants, vinyl resin stabilizers and antioxidants[1-4]. Bicyclic phosphates are antagonist of GABA receptor, further research show that these compounds act on the chloride ion channel connecting with GABA receptor. So bicyclic phosphate can act as drugs to probe the Cl- channel. Our preliminary pharmacological results indicate that these bicyclic phosphorus compounds should be handled with great care because of their high toxicity to mammals. Some derivatives of bicyclic phosphates have been prepared in our laboratory.
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