高等学校化学学报

高等学校化学学报 ›› 1998, Vol. 19 ›› Issue (S1): 129.

• Organic Synthesis Chemistry • 上一篇    下一篇

Synthesis and Structure-Activity Relationships of Anticholinergics of Dibenzo[b,e] oxepin(thiepin) Hydroxycarboxylates

Gao Shouhai, Yun Liuhong   

  1. Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences, Beijing 100850
  • 出版日期:1998-12-31 发布日期:1998-12-31

Synthesis and Structure-Activity Relationships of Anticholinergics of Dibenzo[b,e] oxepin(thiepin) Hydroxycarboxylates

Gao Shouhai, Yun Liuhong   

  1. Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences, Beijing 100850
  • Online:1998-12-31 Published:1998-12-31

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摘要： In order to investigate the relationships between the conformations of tricyclic hydroxycarboxylates and their anticholinergic activities, and to explore the effects of changing the linking groups between the two benzene rings in tricyclic compounds on anticholinergic activities and on the selectivity to the central nicotinic receptor, a series of new tricyclic anticholinergic compounds-dibenzo[b,e]oxepin (thiepin) hydroxycarboxylates (Fig. 1) were designed and synthesized.

Abstract: In order to investigate the relationships between the conformations of tricyclic hydroxycarboxylates and their anticholinergic activities, and to explore the effects of changing the linking groups between the two benzene rings in tricyclic compounds on anticholinergic activities and on the selectivity to the central nicotinic receptor, a series of new tricyclic anticholinergic compounds-dibenzo[b,e]oxepin (thiepin) hydroxycarboxylates (Fig. 1) were designed and synthesized.

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