高等学校化学学报 ›› 1998, Vol. 19 ›› Issue (S1): 123.
• Organic Synthesis Chemistry • 上一篇 下一篇
Fu-Chang Shu, Chun-Xiao Xu, Qi-Lin Zhou
Fu-Chang Shu, Chun-Xiao Xu, Qi-Lin Zhou
摘要: The synthesis of cyclopropane amine has attracted considerable interest from organic chemists because of the biologically importance and its occurrence in numerous natural products1. Several synthetic cyclopropane amines have been used as drugs, e.g. the monoamine oxidase inhibitor tranylcypromine (1)2. However, it has been found that two enantiomers of chiral cyclopropane amine have different pharmacological effects3,which demands organic chemists to develop efficient methods to prepare them enantioselectively. Previous synthesis of enantiomerically pure cyclopropane amines involves resolution of racemic cyclopropane carboxylic acid followed by Curtius degradation4.
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