高等学校化学学报 ›› 1998, Vol. 19 ›› Issue (S1): 123.

• Organic Synthesis Chemistry • 上一篇    下一篇

A Catalytic Enantioselective Synthesis of Biologically Interesting Cyclopropane Amines

Fu-Chang Shu, Chun-Xiao Xu, Qi-Lin Zhou   

  1. Institute of Fine Chemicals, East China University of Science and Technology Shanghai 200237
  • 出版日期:1998-12-31 发布日期:1998-12-31
  • 基金资助:
    Financial support by Chinese National Science Foundation (29772008),Foundation of Chinese Extraordinary Young Scientists and Laboratory of Organometallic Chemistry,Chinese Academy of Sciences is gratefully acknowledged

A Catalytic Enantioselective Synthesis of Biologically Interesting Cyclopropane Amines

Fu-Chang Shu, Chun-Xiao Xu, Qi-Lin Zhou   

  1. Institute of Fine Chemicals, East China University of Science and Technology Shanghai 200237
  • Online:1998-12-31 Published:1998-12-31
  • Supported by:
    Financial support by Chinese National Science Foundation (29772008),Foundation of Chinese Extraordinary Young Scientists and Laboratory of Organometallic Chemistry,Chinese Academy of Sciences is gratefully acknowledged

摘要: The synthesis of cyclopropane amine has attracted considerable interest from organic chemists because of the biologically importance and its occurrence in numerous natural products1. Several synthetic cyclopropane amines have been used as drugs, e.g. the monoamine oxidase inhibitor tranylcypromine (1)2. However, it has been found that two enantiomers of chiral cyclopropane amine have different pharmacological effects3,which demands organic chemists to develop efficient methods to prepare them enantioselectively. Previous synthesis of enantiomerically pure cyclopropane amines involves resolution of racemic cyclopropane carboxylic acid followed by Curtius degradation4.

Abstract: The synthesis of cyclopropane amine has attracted considerable interest from organic chemists because of the biologically importance and its occurrence in numerous natural products1. Several synthetic cyclopropane amines have been used as drugs, e.g. the monoamine oxidase inhibitor tranylcypromine (1)2. However, it has been found that two enantiomers of chiral cyclopropane amine have different pharmacological effects3,which demands organic chemists to develop efficient methods to prepare them enantioselectively. Previous synthesis of enantiomerically pure cyclopropane amines involves resolution of racemic cyclopropane carboxylic acid followed by Curtius degradation4.

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