高等学校化学学报

高等学校化学学报 ›› 1998, Vol. 19 ›› Issue (S1): 105.

• Organic Synthesis Chemistry • 上一篇    下一篇

Fe2(SO4)3·xH2O CATALYTIC ESTERIFICATION OF MANDELIC ACID WITH ALCOHOLS

Hui Gong1, Gui-Sheng Zhang1, Huai-Zhou Li2   

  1. 1. Department of Chemistry, Henan Normal University, Xinxiang 453002;
    2. Basic Medical College, Henan Medical Uiversity, Zhengzhou 450052
  • 出版日期:1998-12-31 发布日期:1998-12-31

Fe2(SO4)3·xH2O CATALYTIC ESTERIFICATION OF MANDELIC ACID WITH ALCOHOLS

Hui Gong1, Gui-Sheng Zhang1, Huai-Zhou Li2   

  1. 1. Department of Chemistry, Henan Normal University, Xinxiang 453002;
    2. Basic Medical College, Henan Medical Uiversity, Zhengzhou 450052
  • Online:1998-12-31 Published:1998-12-31

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摘要： Mandelates have played an important role in organic synthesis and are used in artificial flavorings and perfumes. Mandelates may be prepared as follows:1). Direct esterification of mandelic acid with alcohols in the presence of sulfuric acid1,2 or 2,2-dimethoxypropane and sulfuric acid;3 2). Treatment mandelic acid and iodide in the presence of sodium hydrogen carbonate;4 3). Treatment mandelic acid and alcohols with thionyl chloride.5 But these methods have some advantages and are not universally applicable. For example, the direct esterification catalyzed by sulfuric acid is not suitable for acid sensitive compounds and has the disadvantages of the corrosivity of strong acid and usually accompanying side reactions such as carbonization,oxidation, etherification, etc. We now reported the catalytic esterification of mandelic acid with a serious of alcohols using Fe2(SO4)3·xH2O as a new convenient catalyst.

Abstract: Mandelates have played an important role in organic synthesis and are used in artificial flavorings and perfumes. Mandelates may be prepared as follows:1). Direct esterification of mandelic acid with alcohols in the presence of sulfuric acid1,2 or 2,2-dimethoxypropane and sulfuric acid;3 2). Treatment mandelic acid and iodide in the presence of sodium hydrogen carbonate;4 3). Treatment mandelic acid and alcohols with thionyl chloride.5 But these methods have some advantages and are not universally applicable. For example, the direct esterification catalyzed by sulfuric acid is not suitable for acid sensitive compounds and has the disadvantages of the corrosivity of strong acid and usually accompanying side reactions such as carbonization,oxidation, etherification, etc. We now reported the catalytic esterification of mandelic acid with a serious of alcohols using Fe2(SO4)3·xH2O as a new convenient catalyst.

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