高等学校化学学报

高等学校化学学报 ›› 1998, Vol. 19 ›› Issue (S1): 1.

• Plenary, Keynote and Invited Lectures •    下一篇

Nature's Strategy for Making Unusual Sugars

Hung-wen Liu   

  1. Department of Chemistry, University of Minnesota, Minneapolis, MN 55455, U. S. A
  • 出版日期:1998-12-31 发布日期:1998-12-31

Nature's Strategy for Making Unusual Sugars

Hung-wen Liu   

  1. Department of Chemistry, University of Minnesota, Minneapolis, MN 55455, U. S. A
  • Online:1998-12-31 Published:1998-12-31

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摘要： The deoxy sugars are an important class of carbohydrates that are derived from common sugars by the replacement of one or more hydroxyl groups with hydrogen atoms. Such a substitution generally causes a critical alteration of the biological role of the resulting sugar, and olso induces a fundamental change in the metabolic fate of the product. Particularly notable are the 3,6-dideoxyhexoses found in the lipo-polysaccharides of gram-negative bacteria and the 2,6- and 4,6-dideoxyhexoses found in many bioactive secondary metabolites. Intrigued by the great variety of the biological activities and structural features of deoxy sugars, we have undertaken an investigation into the biosynthesis of this important class of molecules. In the past few years we have focused our efforts on the formation of ascarylose, a 3,6-dideoxy sugar, and other related deoxy sugars from Yersinia pseudotuberculosis. The first part of this presentation will cover the establishment of the course of each multi-step biotransformation and the characterization of the key enzymes involved in this pathway.

Abstract: The deoxy sugars are an important class of carbohydrates that are derived from common sugars by the replacement of one or more hydroxyl groups with hydrogen atoms. Such a substitution generally causes a critical alteration of the biological role of the resulting sugar, and olso induces a fundamental change in the metabolic fate of the product. Particularly notable are the 3,6-dideoxyhexoses found in the lipo-polysaccharides of gram-negative bacteria and the 2,6- and 4,6-dideoxyhexoses found in many bioactive secondary metabolites. Intrigued by the great variety of the biological activities and structural features of deoxy sugars, we have undertaken an investigation into the biosynthesis of this important class of molecules. In the past few years we have focused our efforts on the formation of ascarylose, a 3,6-dideoxy sugar, and other related deoxy sugars from Yersinia pseudotuberculosis. The first part of this presentation will cover the establishment of the course of each multi-step biotransformation and the characterization of the key enzymes involved in this pathway.

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