关键词: 1,3,4-噻二唑, 硫脲, 异硫氰酸苯酯

Abstract:

Thioureas have been widely applied in pesticides and pharmaceuticals because of their unique biological activities, such as insecticidal, anti-inflammatory, anti-allergic, antiviral, antibacterial, etc. And thiodiazole derivatives usually have anti-allergic, alexipharmic and regulation of plant growth biological activity. The compounds containing thiourea and thiodiazole would provide better biological activities simultaneously according biological activity of the superposition principle. A series of thioureas containing thiodiazole was synthesized from thiodiazole-2-aminomethyl phenols and phenyl isothiocyanate in moderate to good yields. The reaction condition was warm and the scope of substrates was wide. Furthermore, the thiodiazole-2-aminomethyl phenols reacted with a more active reagent dimethylcarbamothioic chloride to afford novel product with thiourea and carbamothioate groups simultaneously. The reactions could afford good results by stirring for 90 min under 60 ℃ and the disubstituted product 5 was the major product. All the new products have the potential applied in pesticides and pharmaceuticals. The structures of the products were characterized by IR, ¹H NMR, ¹³C NMR and HRMS.

Key words: 1,3,4-Thiodiazole, Thiourea, Phenyl isothiocyanate