高等学校化学学报

高等学校化学学报 ›› 2013, Vol. 34 ›› Issue (2): 479.doi: 10.7503/cjcu20120522

• 高分子化学 • 上一篇    下一篇

羧基化氧化石墨烯-谷氨酸复合物的抗凝血性能

顾皓1,2, 周宁琳1,2,3, 樊云婷1,2, 王晓丹1,2, 李文秀1,2, 沈健1,2,3   

  1. 1. 南京师范大学化学与材料科学学院, 江苏省生物医药功能材料工程研究中心, 南京 210023;
    2. 江苏省生物功能材料重点实验室, 南京 210023;
    3. 南京大学, 江苏省表面与界面工程技术研究中心, 南京 210093
  • 收稿日期:2012-05-29 出版日期:2013-02-10 发布日期:2013-01-21
  • 通讯作者: 周宁琳,女,博士,教授,博士生导师,主要从事纳米技术和生物医用材料研究.E-mail:zhouninglin@njnu.edu.cn E-mail:zhouninglin@njnu.edu.cn
  • 基金资助:

    江苏省"六大人才高峰"高层次人才项目(批准号: NY-031)、 江苏高校优势学科建设工程资助项目(批准号: PAPD)和江苏省产学研前瞻性联合研究项目(批准号: BY2011109)资助.

Anticoagulant Properties on Carboxylated Graphene Oxide-Glutamic Acid Composite

GU Hao1,2, ZHOU Ning-Lin1,2,3, FAN Yun-Ting1,2, WANG Xiao-Dan1,2, LI Wen-Xiu1,2, SHEN Jian1,2,3   

  1. 1. Jiangsu Engineering Research Center for Biomedical Function Materials, College of Chemistry and Materials Science, Nanjing Normal University, Nanjing 210023, China;
    2. Jiangsu Province Key Laboratory of Biofunctional Materials, Nanjing 210023, China;
    3. Jiangsu Province Technological Research Center for Interfacial Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093, China
  • Received:2012-05-29 Online:2013-02-10 Published:2013-01-21
  • Contact: ZHOU Ning-Lin E-mail:zhouninglin@njnu.edu.cn

PDF (PC)

被引次数

25

摘要：

将手性的L-谷氨酸(Glu)接枝到羧基化氧化石墨烯片层上, 制备了一种羧基化氧化的氧化石墨烯-谷氨酸复合物(GeneO-Glu), 提高了羧基化的氧化石墨烯的生物相容性. 利用红外光谱、 静态水接触角、 X射线衍射及热重分析等手段对所合成的GeneO-Glu复合物进行了表征, 并对其复合机理进行了探讨. 结果表明, Glu可在一定条件下通过化学反应键合在羧基化的氧化石墨烯片层上. 血浆复钙时间随着复合物浓度的增加而增加; 不同pH值条件下合成的复合物在不同浓度下的溶血率均小于5%, GeneO-Glu复合物在低浓度时即表现出优良的抗凝血性能.

关键词: 羧基化氧化石墨烯, L-谷氨酸, 溶血实验, 复钙时间

Abstract:

Anticoagulation properties of biomaterials are crucial for biomedical applications, especially for blood-contacting materials. Carboxylated graphene oxide complexes with L-glutamic acid was prepared. The complexes were characterized by FTIR, static contact angle(SCA), XRD and TG. The anticoagulation properties of complexes were evaluated by hemolysis test and recalcification time test. The results show that the L-glutamic acid has been coordinated on graphene oxide sheet layer. The plasma recalcification time were prolonged greatly as compared to whole blood. At lower concentrations, the hemolysis rates was less than 5%, which met the requirements of biomedical materials.

Key words: Carboxylated graphene oxide, L-Glutamic acid, Hemolysis test, Plasma recalcification time

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