A Review of the Toxic Effects of Al on the Biological Functions of Fe, Ca and Mg and Related Toxic Mechanisms

Abstract

Abstract:

Aluminum (Al) is not an essential element for human body. On the contrary, Fe,Ca, and Mg are required to mediate many normal metabolisms. However, because of the resemblance of both ionic diameters and ionic charges between Al and Fe, Ca, and Mg,Al expects to disturb the biological activities of its analogues. In this paper, the recent progresses of the studies of the toxic effects of Al on the biological functions of Fe, Ca and Mg have been reviewed. The corresponding mechanisms of the toxicogenic action of Al in these cases are also discussed. A typical toxicity of Al is resulted from its promotion of the ability of Fe to produce free radical or reactive oxidants that will lead to 'oxidative stress',one of the factors of the pathology of Alzhmers disease and Parkinson's disease. The substitutions of Fe and Ca for Al in some biological functional components will result in anemia and osteopathia respectively as well. In addition, fifty references have been cited.

Key words: Aluminum, Iron, Calcium, Magnesium, Review

CLC Number:

B10403

TrendMD:

ZHANG Fu-Ping, BI Shu-Ping, GAN Ning, LIU Jian, YANG Li. A Review of the Toxic Effects of Al on the Biological Functions of Fe, Ca and Mg and Related Toxic Mechanisms[J]. Chem. J. Chinese Universities, 2001, 22(S1): 59.

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A Review of the Toxic Effects of Al on the Biological Functions of Fe, Ca and Mg and Related Toxic Mechanisms

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