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Design， Synthesis and Fungicidal Activity of Pyrazinamide Analogs WANG Gang, LIANG Shuang, SHAN Zhonggang, YING Junwu, LYU Liang, LI Bin, YANG Huibin Chem. J. Chinese Universities    2024, 45 (10): 20240369-.   DOI: 10.7503/cjcu20240369 Abstract （314）   HTML （14）    PDF（pc） （4355KB）（5467）       Knowledge map    Save Pyraziflumid was a novel pyrazinamide analog fungicide developed by Nihon Nohyaku Co. In this work， 16 pyrazinamide analogs were synthesized using substituted pyrazine acid and 2-methyl-3-nitrophenol as initial materials through 4 steps. The structures of the target compounds were confirmed by nuclear magnetic resonance （1H NMR， 13C NMR） and high resolution mass spectrometer（HRMS）. The results of fungicidal activity at greenhouse showed that pyrazinamide analogs had excellent fungicidal activities against corn rust at 6.25 mg/L. Among them， the fungicidal activities of compounds 4， 5， 7， 8， 15 and 16 against corn rust at 6.25 mg/L were 100%. Molecular docking simulations revealed that compound 16 interacted with TRP-173 of succinate dehydrogenase（SDH） through hydrogen bonding， which could explain the probable mechanism of action between compound 16 and the target protein. These results indicated that compound 16 might be a promising fungicide candidate and provide valuable reference for further investigation. Table and Figures | Reference | Related Articles | Metrics

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Research Progress on the Molecular Structure of Amorphous Chalcogen Elements SHI Wuyi, BAO Yu, CUI Shuxun Chem. J. Chinese Universities    2024, 45 (6): 20240054-.   DOI: 10.7503/cjcu20240054 Abstract （455）   HTML （43）    PDF（pc） （6540KB）（647）       Knowledge map    Save Chalcogen elements（including sulfur， selenium， and tellurium） are essential substances in the nature and have wide-range applications in photoelectric materials， batteries， semiconductors， and other fields. Chalcogen elements have two structural forms： crystalline and amorphous. While the molecular structure of crystalline chalcogen elements has been extensively investigated， the molecular structures of amorphous chalcogen elements remain uncertain. To better explore the potential applications of amorphous chalcogen elements， it is necessary to study their structure and properties. This paper summarizes recent advancements in understanding the molecular structure of amorphous chalcogen elements and envisages potential research directions. These efforts aim to contribute to a more comprehensive understanding of the properties of amorphous chalcogen elements and to foster their application across diverse fields. Table and Figures | Reference | Related Articles | Metrics

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Cover and Content of Chemical Journal of Chinese Universities Vol.45 No.11(2024) Chem. J. Chinese Universities    2024, 45 (11): 1-6.   Abstract （215）      PDF（pc） （19537KB）（536）       Knowledge map    Save Related Articles | Metrics

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Internal Standard Method-based Surface-enhanced Raman Spectroscopy for Quantitative Analysis BI Yingna, LIU Dingbin Chem. J. Chinese Universities    2025, 46 (2): 20240457-.   DOI: 10.7503/cjcu20240457 Abstract （524）   HTML （30）    PDF（pc） （13761KB）（486）       Knowledge map    Save Surface-enhanced Raman spectroscopy（SERS） is a spectral detection method that has been widely used in the fields of disease diagnosis， drug screening， and biological analysis， etc. It can not only provide rich chemical fingerprint information but also has the advantages of high sensitivity， resistance to photobleaching， and photodegradation. However， due to the poor uniformity of its enhancement matrix structure and the uncertainty of the number of chemical molecules adsorbed， the reproducibility of SERS detection results is poor， which makes it face many challenges in quantitative analysis. The deployment of internal standards could eliminate the external interference factors， thus achieving accurate quantitative analysis. We set out this review with a description of the mechanism of internal-standard methods， followed by introducing their main types. Thereafter， we introduced explanations of the applications of internal-standard probes in environmental analysis， food and drug analysis， and biological analysis. We conclude with an outlook of challenges and future development directions of internal-standard SERS. Table and Figures | Reference | Related Articles | Metrics

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Application of Nanozyme-based Micro/nanomotors in Smart Drug Delivery ZHANG Dang, SUN Xiaomin, YANG Haiyue, SONG Bohan, CONG Meng, WANG Yuxin, DING Feng, XU Shanshan, BI Sai, WANG Lei Chem. J. Chinese Universities    2025, 46 (1): 20240468-.   DOI: 10.7503/cjcu20240468 Abstract （365）   HTML （14）    PDF（pc） （17644KB）（455）       Knowledge map    Save To solve the problems of instability， inactivation of natural enzymes and to tackle the limitations of low delivery efficiency， nanozyme-based micro/nanomotors have been designed and prepared. These motors， with the combination of the efficient and stable catalytic ability of nanozyme and the autonomous motion capability of micro/ nanomotors， could achieve active targeted drug delivery at the diseased site and respond to specific signals for intelligent and controllable drug release， therefore exhibiting significant potential in smart drug delivery applications. Following the developing idea of “from motility， to controllability and applicability”， this paper provides a comprehensive review of various types of nanozymes， discusses the motion regulatory strategies of micro/nanomotors， systematically reviews the cutting-edge applications of nanozyme-based micro/nanomotors in precision drug delivery， and summarizes the challenges and future development prospects for this technology in practical application， wishing to provide fundamental guidance for the development of this field. Table and Figures | Reference | Related Articles | Metrics

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Research Progress on Eutectic Gallium-indium and Self-assembled Monolayer-based Functional Molecular Junctions CHEN Xiaoping, HUANG Shi, GUO Qianqian, LIU Ning, NI Jiancong, YANG Weiqiang, LIN Zhenyu Chem. J. Chinese Universities    2025, 46 (2): 20240451-.   DOI: 10.7503/cjcu20240451 Abstract （424）   HTML （14）    PDF（pc） （14619KB）（424）       Knowledge map    Save Functional molecular electronics based on eutectic gallium⁃indium as top electrode and self-assembled monolayer（SAM） as active layer is one of the research hotspots in recent years. Domestically， the study on EGaIn-based functional molecular junctions（MJ） is still in the beginning state. This review introduces the advantages of EGaIn as top electrode and the fabrication of SAM-MJ in detail， and shows recent workers on rectifiers， memory， opto-electrical switches， thermoelectrics， and solid-state impedance and so on. We analyze the challenges of EGaIn-based molecular junctions and propose the future development directions. Table and Figures | Reference | Related Articles | Metrics

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First-principles Study on the Catalysis of OER/ORR by N-doped Graphene with Defects HUANG Zhiyao, LI Li, XU Huaqing, YANG Yifan, WEI Yaoyao, LIU Guokui, XIA Qiying Chem. J. Chinese Universities    2025, 46 (2): 20240430-.   DOI: 10.7503/cjcu20240430 Abstract （450）   HTML （14）    PDF（pc） （2927KB）（421）       Knowledge map    Save Non-metallic doped graphene-based catalysts have good application prospects in catalyzing oxygen evolution reaction（OER） and oxygen reduction reaction（ORR）. Based on the common double vacancy defects of graphene， non-metallic N-doped catalytic material was constructed and all possible active sites were studied. Through DFT calculation， we find that none of the 13 carbon active sites can effectively adsorb H2O， while O2 can be effectively adsorbed. The calculation results show that the optimal catalytic site for ORR is C12， with the overpotential of 0.71 V for catalyzing ORR， followed by the C10 site adjacent to pyridine N and C3 site， with the overpotentials of 0.75 V and 0.78 V， respectively. This study demonstrates that non-metallic N-doped defective graphene materials can be applied to catalyze ORR， providing theoretical support and guidance for non-metallic catalysis in the OER/ORR reactions. Table and Figures | Reference | Supplementary Material | Related Articles | Metrics

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Synthesis and Temperature Control Performance of Silica Gel Waste Composite Phase Change Materials XIE Zhuoxue, KOU Yan, SHI Quan, TIAN Ying Chem. J. Chinese Universities    2025, 46 (2): 20240372-.   DOI: 10.7503/cjcu20240372 Abstract （348）   HTML （16）    PDF（pc） （6908KB）（398）       Knowledge map    Save In this study， silica gel waste（SGW） was utilized to prepare porous silicon dioxide（PSD） as a carrier， combined with capric acid-hexadecyl alcohol（DA-HD） as the base phase change material（PCM）， to develop the composite PCM capric acid-hexadecyl alcohol/porous silicon dioxide（PSD-DA-HD）. Expanded graphite（EG） was introduced to enhance the thermal conductivity of the material. The thermal performance of the composite PCM was evaluated using differential scanning calorimetry（DSC）， thermogravimetric analysis（TGA）， and thermal constant analysis. The composite PCM was then blended with cement mortar to form phase change mortar， and its temperature regulation capability was studied in simulated application experiments. The results indicate that DA-HD is physically encapsulated within the pores of PSD， achieving a loading capacity of 61.7%， with an enthalpy value of 105.6 J/g. The PSD-DA-HD composite PCM demonstrates good shape stability. The introduction of expanded graphite increased the thermal conductivity of the PSD/EG-DA-HD composite PCM to 0.9513 W·m‒1·K‒1 but reduced its loading capacity to 49.5%， with an enthalpy value of 88.1 J/g. Both PSD-DA-HD and PSD/EG-DA-HD exhibit a maximum working temperature of 92.2 ℃， ensuring thermal stability below this threshold. When PSD-DA-HD and PSD/EG-DA-HD were mixed with cement mortar， the resulting phase change mortars displayed excellent heat storage and temperature regulation properties. The phase change mortars C-PSD-DA-HD and C-PSD/EG-DA-HD maintained stable temperatures for 12.7 and 6.7 min， respectively， within the temperature range of 18—32 ℃. In the simulation experiments， the phase change mortar containing PSD-DA-HD extended the temperature regulation duration by 267.92% compared to the control group without PCMs in the same temperature range. Table and Figures | Reference | Supplementary Material | Related Articles | Metrics

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Influence of Polycyclic Aromatic Hydrocarbon Molecular Framework on Single-molecule Conductance WANG Mingzhen, WANG Zhiye, LI Mengxiao, LU Yuhua, WANG Xu, LI Yunchuan Chem. J. Chinese Universities    2025, 46 (2): 20240429-.   DOI: 10.7503/cjcu20240429 Abstract （443）   HTML （15）    PDF（pc） （4103KB）（397）       Knowledge map    Save The charge transport process within molecular junctions is influenced by many factors， including the molecular backbones and anchoring groups. In this paper， to investigate the impact of the molecular backbone on the charge transport properties of molecular junctions， we designed and synthesized three kinds of polycyclic aromatic hydrocarbons（PAHs） with different fused-ring core（benzene， naphthalene and anthracene） as molecular skeleton and thiophene as anchor group. Scanning tunneling microscope break junction（STM-BJ） measurement and density functional theory（DFT） -based calculations were performed to investigate the charge transport process of single PAHs junctions. The STM experimental results of three molecules exhibit two distinct conductivity states， designated as high conductance states（GH） and low conductance states（GL）， which correspond to the two binding configurations of Au-π and Au-S within single molecular junctions for three molecules. In the case of the GL state， the increase of fused-ring core effectively shifts the HOMO level closer to the Au Fermi level， resulting in a conductance trend of GDT-A>GDT-N>GDT-B. In the GH state， the conductance value of three molecular junctions will not change obviously with the increase of π-conjugated area， but the increase in twist angle of PAHs results in an enhancement of steric hindrance， which reduces the probability of Au-π bonding configuration， ultimately leading to a change in the formation ratio of the two molecular configurations of Au-π and Au-S. Table and Figures | Reference | Supplementary Material | Related Articles | Metrics

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In situ Cupric Complexation Regulated Fenton-like Oxidation to Enhance the Selective Decontamination of Trace Aqueous Quinolones ZENG Xiangchu, DING Yixuan, WU Zhe, WANG Yanping, LIU Mu Chem. J. Chinese Universities    2025, 46 (3): 20240358-.   DOI: 10.7503/cjcu20240358 Abstract （267）   HTML （9）    PDF（pc） （6779KB）（380）       Knowledge map    Save As one of the emerging aqueous contaminants， quinolones have attracted extensive attention， and selective decontamination is one of the effective methods to solve this setbacks. Therefore， a homogeneous Fenton-like oxidation system of cupric complexes activated peroxymonosulfate（PMS） was proposed for the removal of trace quinolones（QNs） from water. Over a wide pH range， over 99% of QNs can be degraded within 60 min， but they are also free from the influence of natural organic matter（up to 1%） and various anions（up to 20%）. The activation of peroxymonosulfate by cupric complexes coupling Cu（Ⅲ） complexes generation in situ promoted an intramolecular electron transfer featuring selective oxidation of QNs. The generated Cu（Ⅲ） and ·OH played the primary and secondary role in the degradation of QNs， respectively. This work provides a successful case and feasibility for the selective decontamination of trace antibiotics via cupric complexes activated PMS Fenton-like oxidation system. Table and Figures | Reference | Related Articles | Metrics

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Theoretical Study of the Effect of Conformational Structures on the Secondary Oxidation Reactions of cis-1，3-Dimethylcyclohexane SHEN Yuhao, TIAN Zemin, LI Wei, JI Yixuan, YAN Yingwen Chem. J. Chinese Universities    2025, 46 (3): 20240458-.   DOI: 10.7503/cjcu20240458 Abstract （259）   HTML （4）    PDF（pc） （5108KB）（365）       Knowledge map    Save In this study， quantum chemistry method of DLPNO-CCSD（T）/CBS//B3LYP/6-311++G（d，p） was applied for low-temperature secondary oxidation reactions of cis-1，3-dimethylcyclohexane， to optimize molecular geometries， compute vibrational frequencies， and refine single point energies of all related reactants， transition states， and products. In this way， the detailed potential energy surfaces for titled reactions were constructed. High pressure limit rate constants of main reaction channels were calculated based on transition state theory. It was shown that side-chain tended to benefit H-transfer channels of hydroperoxy alkylperoxy radicals（OOQOOH）， among which 1，5-H transfer reactions proved of great significance， competing with decomposition channel forming keto-hydroperoxides（KHP） and OH radical. Dihydrogen peroxide radicals［P（OOH）2］ resulted from H-transfer of OOQOOH radical mainly underwent cyclic ether reactions. The energy barriers of these reactions tended to increase due to side chain. Based on Rice-Ramsperger-Kassel-Marcus/master equation（RRKM/ME） method， the pressure-dependent rate constants were obtained， revealing that the effect of pressure on the rate constants of all above reactions was weak. Table and Figures | Reference | Supplementary Material | Related Articles | Metrics

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Understanding the Water Structures in Antifreezing of DMSO Derivatives by Near-infrared Spectroscopy LIANG Fanfan, HAN Li, CAI Wensheng, SHAO Xueguang Chem. J. Chinese Universities    2025, 46 (2): 20240424-.   DOI: 10.7503/cjcu20240424 Abstract （343）   HTML （7）    PDF（pc） （2098KB）（363）       Knowledge map    Save The molecular mechanism of L-methionine sulfoxide［L-Met（O）-OH］， a derivative of dimethyl sulfoxide （DMSO）， in inhibiting ice crystal growth was studied using near-infrared spectroscopy combined with chemometrics. High-resolution spectra were obtained through wavelet packet transform， allowing for a detailed analysis of the NIR spectra of L-Met（O）-OH solutions at various concentrations during the freezing process at -5 ℃. Spectral information regarding the interaction between the S=O group and ice was extracted. The results indicate that the primary reason for the effective inhibition of ice growth by L-Met（O）-OH is the formation of hydrogen bonds between the S=O group and ice. Further analysis of solutions at 0 ℃ revealed spectral features of interactions between water molecules and the S=O and C=O groups in L-Met（O）-OH. During the freezing process， the intensity of the spectral peaks associated with these interactions gradually decreased， indicating that the interactions between the S=O and C=O groups and water molecules weakened， and this weakening effect became more pronounced at higher concentrations. Finally， the role of the NH group in the inhibition of ice crystal growth was investigated. It was found that during freezing， the binding of NH groups to water molecules increased， forming a stable hydrogen-bonded network. The result indicates that the NH group consistently interacts with water throughout the freezing process and does not significantly interact with ice. Table and Figures | Reference | Related Articles | Metrics

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Discovery of CDK2 Inhibitors Based on Machine Learning and Molecular Dynamics Simulations TAN Yingjia, CHEN Liang, LIU Yulin, NA Risong, ZHAO Xi Chem. J. Chinese Universities    2025, 46 (3): 20240442-.   DOI: 10.7503/cjcu20240442 Abstract （300）   HTML （6）    PDF（pc） （7091KB）（359）       Knowledge map    Save Four potential cyclin-dependent kinase 2（CDK2） inhibitors were discovered through machine learning and molecular dynamics simulation methods. First， a classification model for CDK2 inhibitors was established using existing large-scale activity databases and machine learning algorithms. The extreme gradient boosting（XGBoost） model with extended-connectivity fingerprints（ECFP6） was used to screen the Enamine database， identifying 1152 novel compounds. These potential compounds were then ranked based on their affinity for CDK2 using molecular docking and scoring functions. The compounds were clustered into four categories using fingerprint clustering methods， and one compound with a high docking score was selected from each category. Subsequently， the four selected compounds underwent drug-likeness analysis and molecular dynamics simulations. The four potential CDK2 inhibitors（Z1766368563， Z363564868， Z1891240670 and Z2701273053） demonstrated good drug-likeness properties and high binding free energy in molecular dynamics simulation results. The findings suggest that these four compounds can serve as lead compounds for subsequent modification and optimization as CDK2 inhibitors. Table and Figures | Reference | Supplementary Material | Related Articles | Metrics

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ZIF-8 Nanosheet-functionalized Poly（lactic acid） Nanofibrous Membranes for Efficient Filtration of Ultrafine Particles WANG Shengcheng, WANG Cunmin, HAO Yaxin, ZHU Guiying, LI Xinyu, SONG Xinyi, ZHANG Mingming, XU Huan, HE Xinjian Chem. J. Chinese Universities    2025, 46 (2): 20240426-.   DOI: 10.7503/cjcu20240426 Abstract （321）   HTML （15）    PDF（pc） （10193KB）（352）       Knowledge map    Save Zeolite imidazolate framework-8（ZIF-8） nanosheets（ZIF-8-NS） with high specific surface area were prepared by micro-assisted synthesis method， and uniformly dispersed into poly（lactic acid）（PLA） solution as nano-dielectrics， then ZIF-8-NS-functionalized PLA（PLA/ZIF-8-NS） nanofibers were prepared by electrospinning to improve the filtration efficiency and to achieve the long-lasting respiratory protection for the operators. The microstructure and properties of the prepared PLA/ZIF-8-NS nanofibrous membranes were investigated. It was found that the addition of ZIF-8-NS resulted in a significant refinement of PLA/ZIF-8-NS fibers（253 nm） and an increase in fiber surface roughness. The surface potential of PLA/ZIF-8-NS nanofibrous membrane reached 10.4 kV and the dielectric constant reached 2.71， demonstrating excellent charge storage capability. At the same time， the PLA/ZIF-8-NS nanofibrous membrane was given excellent filtration performance for ultrafine particles， and the filtration efficiency for PM0.3 and PM0.3—2.5 reached 95.57% and 99.95% respectively under the high air flow rate of 85 L/min， with an air resistance of 305.3 Pa， and the filtration efficiency for PM0.3 still maintained at a high level of 98.50% after 360 min of filtration. In addition， the PLA/ZIF-8-NS nanofibrous membrane exhibited superior antimicrobial properties， with an inhibition rate of 99.9% against Staphylococcus aureus. These results indicate that PLA/ZIF-8-NS nanofibrous membranes have great potential to achieve long-term filtration and low resistance to ultrafine particles， which can provide an important safeguard for respiratory health protection of personnel operating in high dust concentration environment. Table and Figures | Reference | Related Articles | Metrics

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Ultra-fast Synthesis of Highly Dispersed Pt Nanoparticles Loaded on Carbon Nanotubes by Nanosecond Pulsed Laser for Hydrogen Evolution Reaction WEN Ying, CHEN Rongsheng, NI Hongwei Chem. J. Chinese Universities    2025, 46 (3): 20240464-.   DOI: 10.7503/cjcu20240464 Abstract （256）   HTML （7）    PDF（pc） （15277KB）（350）       Knowledge map    Save The most efficient catalysts for hydrogen evolution reaction（HER） under the acidic environment are still based on platinum group metals and its alloys. Usually， the size and distribution of the active component particles on the carrier of Pt-based catalysts are important factors affecting the activity， selectivity， and stability of the catalysts. In this paper， highly dispersed Pt nanoparticles with uniform size distribution were loaded on multi-walled carbon nanotubes（MWCNT） by nanosecond pulsed laser irradiation for HER applications. Plasma generated by laser irradiation of MWCNT can efficiently reduce H2PtCl6 to metallic Pt atoms， which then assembled highly dispersed Pt nanoparticles of 2—3 nm in diameter on the side walls of MWCNT. The defects caused some Pt nanoparticles to be embedded in the walls of MWCNT during laser irradiation. Comparied with mixed MWCNT/Pt catalysts， electronic interactions between Pt（0） and MWCNT in L-Pt/MWCNT facilitate the reaction kinetics. The L-Pt/MWCNT catalyst exhibited high activity and good stability towards HER， with an overpotential of 39 mV at a current density of 10 mA/cm2 and a Tafel slope of 15 mV/dec. Table and Figures | Reference | Supplementary Material | Related Articles | Metrics

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Advances and Challenges of Exosome Metabolomics in Body Fluids CAO Yiqing, HOU Jingxin, LIU Jianye, LI Yan Chem. J. Chinese Universities    2024, 45 (11): 20240324-.   DOI: 10.7503/cjcu20240324 Abstract （469）   HTML （649）    PDF（pc） （752KB）（334）       Knowledge map    Save Exosomes， ubiquitously present in body fluids， serve as non-invasive biomarkers for disease diagnosis， monitoring， and treatment. As intercellular messengers， exosomes encapsulate a rich array of proteins， nucleic acids， and metabolites， although most studies have primarily focused on proteins and RNA. Recently， exosome metabolomics has demonstrated clinical value and potential advantages in disease detection and pathophysiology， despite significant challenges， particularly in exosome isolation and metabolite detection. This review discusses the significant technical challenges in exosome isolation and metabolite detection， highlighting the advancements in these areas that support the clinical application of exosome metabolomics， and illustrates the potential of exosomal metabolites from various body fluids as biomarkers for early disease diagnosis and treatment. Table and Figures | Reference | Related Articles | Metrics

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Preparation of Carbon Dot-Based Multicolor Room-Temperature Phosphorescent Materials via Precursor Structure Regulation Strategies LIU Jinkun, RAN Zhun, LIU Qingqing, LIU Yingliang, ZHUANG Jianle, HU Chaofan Chem. J. Chinese Universities    DOI: 10.7503/cjcu20240412 Online available: 20 February 2025

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Construction of Chemotherapy-Photothermal Therapy-Self-enhanced Starvation Therapy Nanoplatform and Its Application in Breast Cancer Treatment MA Shuang, LYU Mingyang, ZHANG Citong, LIU Yi Chem. J. Chinese Universities    2025, 46 (1): 20240467-.   DOI: 10.7503/cjcu20240467 Abstract （221）   HTML （5）    PDF（pc） （21821KB）（329）       Knowledge map    Save In recent years， with the continuous development of nanotechnology， multifunctional nanocomposites have been widely applied in the field of tumor therapy. Due to the heterogeneity， complexity， and diversity of tumors， single treatment approaches often fail to achieve ideal therapeutic outcomes. Therefore， combining multiple treatment methods to achieve synergistic tumor therapy has become a research hotspot. This paper designs a novel nanotherapy platform. A polydopamine（PDA） shell was coated on the surface of Pt@mesoporous Au nanomaterials（Pt@Au）， and doxorubicin（DOX） was loaded into the PDA shell. The surface of the PDA shell was modified with glucose oxidase（GOx） and NH2-PEG5K-cRGD. NH2-PEG5K-cRGD can specifically bind to the overexpressed αvβ3 integrin in tumor cells， facilitating the accumulation of the nanotherapy platform in the tumor region. DOX can damage the DNA of tumor cells and is used for chemotherapy. The excellent photothermal properties of mesoporous Au and PDA can be used for photothermal therapy. GOx can react with glucose in tumor cells to produce gluconic acid and H2O2， achieving starvation therapy. Pt， as a common peroxidase mimic， can catalyze the decomposition of H2O2 in tumor cells to generate O2， alleviating the hypoxic tumor microenvironment and promoting starvation therapy. Therefore， the Pt@Au@PDA-DOX-GOx-cRGD possesses the ability to perform chemotherapy-photothermal therapy-self-enhanced starvation therapy for combined tumor treatment. Table and Figures | Reference | Supplementary Material | Related Articles | Metrics

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Cover and Content of Chemical Journal of Chinese Universities Vol.45 No.6(2024) Chem. J. Chinese Universities    2024, 45 (6): 1-5.   Abstract （147）      PDF（pc） （23105KB）（296）       Knowledge map    Save Related Articles | Metrics

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Microfluidic Precise Construction and Performance Studies of HA-zein@QT Nanodrug Delivery System CHEN Minghui, LIU Mohao, LI Yong, CHENG Hang, GENG Peng, QIU Kuncheng, DENG Gaigai, ZENG Jianhong, HUANG Wenquan Chem. J. Chinese Universities    2025, 46 (3): 20240480-.   DOI: 10.7503/cjcu20240480 Abstract （232）   HTML （5）    PDF（pc） （11346KB）（288）       Knowledge map    Save Zein shows great potential in anti-cancer drug delivery systems（DDS）. However， the zein-based DDS prepared by the traditional method has its shortcomings， such as single function， uneven particle size， poor batch reproducibility and anti-cancer effect. In this work， the quercetin（chemical drug）-TCPP（photosensitizer） was used as the model drug（QT）. The co-assembly of the carrier and the model drug was accurately controlled by microfluidic technology. And the HA-zein@QT nanodrug delivery system was precisely constructed to achieve the synergistic anti-tumor. Hyaluronic acid（HA） was used to functionalize α-zein to improve the biocompatibility， stability and cell uptake of the carrier. The microfluidic chip with a high mixing efficiency of 99.54% was screened by computer simulation. The average particle size and PDI of the prepared HA-zein@QT were （50.6±1.7） nm and 0.196， respectively. The results of stability experiments suggested that HA-zein@QT showed high stability after co-incubation with deionized water， PBS and 1640 medium. The results of reactive oxygen species and ·OH detection showed that the 1O2 and ·OH increased after exposure to near-infrared light. HA-zein@QT showed a low hemolysis rate（3.75%） after co-incubation with red blood cells. And a high survival rate（>84.57%） of non-tumor cells was obtained. This evidence indicated that the prepared DDS had high biocompatibility. The cytotoxicity experiment showed that the survival rates of A549， HCT116 and HCT8 cells were 28.2%， 20.2% and 24.6%， respectively. This indicated that HA-zein@QT had a high inhibitory ability to tumor cells. It is expected that the microfluidics precise construction of zein-based DDS will provide a new strategy for achieving high efficiency and minimal side effects in anti-tumor drug delivery. Table and Figures | Reference | Supplementary Material | Related Articles | Metrics