Chem. J. Chinese Universities ›› 1994, Vol. 15 ›› Issue (4): 503.

• Articles • Previous Articles     Next Articles

Studies on the State of Hematoporphyrin(HP) in Physiological Condition Solution

HE Xi-WEn, FENG Xi-Zeng, ZHANG Gui-Zhu, YANG Wan-Long, YU Gui-Ying, SHI Hui-Ming   

  1. Department of Chemistry, Nankai University, Tianjin, 300071
  • Received:1993-05-04 Revised:1993-09-16 Online:1994-04-24 Published:1994-04-24

Abstract: The polymeric state of hematoporphyrin (HP) under physiological conditions and in aqueous solution has been studied by spectrum analysis.From application of Kasha's theory on the difference spectrum between HPmonomer and dimer, we have estimated that the distance between xanthene planes of HPis 0.528 nm and these planes form the cross angle 20°in dimer molecules (Fig.3).The relationship between the energy transmission of HPHSAand the solution state is discussed.The relationship between the photochemical mechanism of curing malignant tumours and the fluorescence character of HP-HSAis discussed.

Key words: Hematoporphyrin(HP), Human serum albumin (HSA), Solution state, Photochemical mechanism

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