Paramagnetic Metal Chelates of DTPA-and EDTA-dipyridoxolester Derivatives and Their NMR T1Relaxivities in Water

Abstract

Abstract: Several novel ligands of DTPAa-nd EDTA-dipyridoxolester derivatives have been synthesized by reaction of DTPA-dianhydride and EDTA-dianhydride with pyridoxol(vitamin B₆) in dry DMF. Their complexes of gadoliniun, manganese and iron were prepared and the measurements of T₁relaxivities in solution of water in vitro were performed with the gadolinium and the manganese complexes. The results show that all of the complexes are highly water soluble and very slightly light and air sensitive both in solid state and in solution. The T₁relaxivities of the complexes, for example, gadolinium-DTPA-dipyridoxolester, GdDTPA-BPN, and manganese-EDTA-dipyridoxolester, MnEDTA-BPN, were determined to be 5.5 and 3.1 L·mmol^-1·s^-1, respectively. These can be compared to the values of the corresponding complexes of their parent ligands, GdDTPA^2-and MnEDTA^2-, indicating the complexes are potentially useful contrast agents for magnetic resonance imaging.

Key words: Magnetic resonance imaging contrast agent, Gadolinium complex, Pyridoxol, Amino-carboxy chelating agent, Relaxivity

CLC Number:

O621.21

TrendMD:

WEI Jun-Fa, ZHUO Ren-Xi. Paramagnetic Metal Chelates of DTPA-and EDTA-dipyridoxolester Derivatives and Their NMR T₁Relaxivities in Water[J]. Chem. J. Chinese Universities, 1998, 19(8): 1242.

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Paramagnetic Metal Chelates of DTPA-and EDTA-dipyridoxolester Derivatives and Their NMR T₁Relaxivities in Water

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